Here’s the detailed profile for Procaine Benzylpenicillin Powder for Injection 1000 mg (≈ 1 million IU) 👇
💉 Procaine Benzylpenicillin Injection 1000 mg (1 million IU)
📘 Description:
- Procaine benzylpenicillin is a long-acting injectable form of benzylpenicillin (penicillin G) combined with procaine (a local anesthetic).
- The procaine salt slows absorption from the injection site → providing sustained blood levels for 12–24 hours.
- Mechanism: Inhibits bacterial cell wall synthesis by binding to PBPs → bactericidal action.
📄 Prescription / Indications:
- Moderate bacterial infections due to penicillin-sensitive organisms:
- Respiratory tract infections (Streptococcus pyogenes, S. pneumoniae)
- Skin & soft tissue infections
- Syphilis (when benzathine penicillin not available/appropriate)
- Gonorrhea (historical use, less common now due to resistance)
- Anthrax, diphtheria, tetanus (as part of combination therapy)
- Rheumatic fever prophylaxis (alternative to benzathine penicillin in some cases)
🌿 Nature / Drug Class:
- β-lactam antibiotic
- Natural penicillin (Penicillin G derivative)
- Depot injection (slow-release IM formulation)
✅ Advantages:
- Provides sustained penicillin levels with single daily injection
- Reduces dosing frequency compared to aqueous benzylpenicillin
- Local anesthetic procaine reduces injection site pain
- Useful in outpatient treatment where IV therapy is not feasible
⚠️ Precautions:
Contraindications:
- History of penicillin or β-lactam allergy
- Severe immediate hypersensitivity (anaphylaxis risk)
Use with caution in:
- Asthma, atopy, multiple allergies (↑ allergy risk)
- Renal impairment (dose adjustment may be required)
- Newborns (risk of kernicterus with high doses)
Adverse effects:
- Pain, redness, or induration at injection site
- Allergic reactions (rash → anaphylaxis)
- Jarisch–Herxheimer reaction (esp. in syphilis treatment)
- Rare neurovascular complications if inadvertently injected IV
💊 Dosage (Adults):
- 600,000 – 1.2 million IU IM once daily (depending on infection type & severity)
- For syphilis: 1.2–2.4 million IU IM daily for 10–14 days
- Pediatric doses: weight-based (typical: 25,000–50,000 IU/kg IM daily)
📦 Common Packaging:
- Glass vials containing 1 million IU powder (≈ 1000 mg)
- Must be reconstituted with sterile water for injection before use
❄️ Storage Conditions:
- Store in cool, dry place (<25°C)
- Protect from light & moisture
- Use reconstituted solution immediately (unstable in solution)