Phenoxymethyl penicillin Tablet 250 mg

Here’s the detailed profile for Phenoxymethylpenicillin (Penicillin V) Tablet 250 mg 👇

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💊 Phenoxymethylpenicillin (Penicillin V) Tablet 250 mg

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📘 Description:

• Phenoxymethylpenicillin (Penicillin V) is an oral penicillin antibiotic.
• It is an acid-stable natural penicillin, suitable for oral administration (unlike Penicillin G).
• Mechanism: Inhibits bacterial cell wall synthesis by binding to penicillin-binding proteins (PBPs) → weakens cell wall → bactericidal.

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📄 Prescription / Indications:

• Streptococcal pharyngitis & tonsillitis (Streptococcus pyogenes)
• Scarlet fever
• Rheumatic fever prophylaxis (long-term)
• Mild to moderate skin infections caused by streptococci
• Dental infections and prophylaxis before dental procedures in at-risk patients (endocarditis prophylaxis)

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🌿 Nature / Drug Class:

• β-lactam antibiotic
• Natural penicillin
• Narrow-spectrum antibacterial (mainly Gram-positive bacteria)

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✅ Advantages:

• Effective against streptococcal infections
• Oral dosage form (unlike benzylpenicillin, which is injectable)
• Low toxicity and well tolerated
• Preferred agent for rheumatic fever prophylaxis in children and adults

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⚠️ Precautions:

Contraindications:

• Hypersensitivity to penicillins or β-lactams (risk of anaphylaxis)

Use with caution in:

• History of asthma, atopy, or multiple allergies (↑ risk of allergic reaction)
• Renal impairment (dose adjustment may be required)

Adverse effects:

• GI upset (nausea, vomiting, diarrhea)
• Skin rash, urticaria
• Rare but serious: anaphylaxis, Stevens-Johnson syndrome, serum sickness
• Long-term use may cause superinfection (e.g., Candida)

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💊 Dosage (Adults):

• 250–500 mg every 6–8 hours depending on infection
• For rheumatic fever prophylaxis: 250 mg twice daily

(Pediatric dosing is weight-based; typically 25–50 mg/kg/day in divided doses)

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📦 Common Packaging:

• Strip packs of 10 tablets
• Bottles / hospital packs (100 or more tablets)

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❄️ Storage Conditions:

• Store at room temperature (<25°C)
• Protect from light & moisture
• Keep tightly closed & out of reach of children

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