Here is a detailed, brand-free, patient leaflet-style overview of Mifepristone Tablet 200 mg:
💊 Mifepristone Tablet 200 mg
✅ DESCRIPTION
Mifepristone is an antiprogestin medication used to medically terminate early pregnancy, manage certain gynecological conditions, and as part of treatment in some endocrine disorders. It works by blocking the action of progesterone, a hormone essential for pregnancy maintenance.
🧪 FORMULATION
- Active Ingredient: Mifepristone 200 mg
- Dosage Form: Oral tablet
- Route: Oral administration
- Tablet Appearance: Usually round or oval, uncoated/coated
🌿 NATURE
- Type: Steroid compound
- Pharmacological Class: Antiprogestin (Progesterone receptor antagonist)
- Mechanism of Action:
- Binds to progesterone receptors and blocks progesterone, leading to detachment of the gestational sac and softening of the cervix, making the uterus more sensitive to prostaglandins.
💊 USES
- Medical Termination of Intrauterine Pregnancy (up to 10 weeks gestation) – used in combination with misoprostol
- Missed abortion (non-viable pregnancy)
- Cervical ripening before surgical abortion
- Management of Cushing’s syndrome (in specific cases)
- Endometriosis or fibroids (investigational/off-label uses)
🌟 ADVANTAGES
- Non-invasive option for early pregnancy termination
- High efficacy and safety when used properly
- Avoids anesthesia and surgery
- Can be administered in outpatient or home settings (as per protocols)
⚠️ PRECAUTIONS
Contraindications:
- Ectopic pregnancy (outside the uterus)
- Undiagnosed abdominal pain
- Chronic adrenal failure
- Hemorrhagic disorders or anticoagulant therapy
- Hypersensitivity to mifepristone or components
- Long-term corticosteroid therapy
Common Side Effects:
- Abdominal cramps, pain
- Vaginal bleeding (usually starts within 24–48 hours)
- Nausea, vomiting, diarrhea
- Headache, fatigue
Serious Risks (Rare):
- Excessive bleeding requiring transfusion
- Incomplete abortion (may require surgical evacuation)
- Infection/sepsis symptoms: fever, chills, foul discharge
Monitoring:
- Follow-up visit is mandatory within 7–14 days
- Confirm complete expulsion of products of conception via ultrasound
📅 DOSAGE (Adult)
- Single dose of 200 mg orally
- Followed 24–48 hours later by misoprostol (dose and route as per guidelines)
🚫 NOT FOR USE IN:
- Breastfeeding women (small amounts pass into milk; consult doctor)
- Advanced pregnancy (>10 weeks)
- Suspected ectopic pregnancy
- Without medical supervision
🧊 STORAGE
- Store below 25°C in a dry place
- Protect from light and moisture
- Keep out of reach of children
- Do not use beyond expiry date