Here is the complete medical information for Itraconazole Oral Liquid 10 mg/mL:
💧 Itraconazole Oral Solution 10 mg/mL
🧪 Generic Name:
Itraconazole
📦 Strength & Form:
- Oral Liquid: 10 mg/mL
- Usually available in 150 mL or 200 mL bottles
🩺 Indications / Uses:
Itraconazole oral liquid is especially indicated for:
- Oropharyngeal candidiasis (especially in HIV/AIDS patients)
- Esophageal candidiasis
- Systemic fungal infections when patient cannot swallow capsules
- Prophylaxis in neutropenic or immunocompromised patients (e.g., bone marrow transplant)
⚖️ Dosage Guidelines:
- Oropharyngeal candidiasis:
- 200 mg/day (20 mL) for 1–2 weeks
- Continue 1 more week if needed
- Esophageal candidiasis:
- 200 mg/day to 400 mg/day (20–40 mL) in 1–2 divided doses
- Duration: 2–4 weeks
- Prophylaxis (e.g., neutropenic patients):
- 200 mg/day (20 mL)
✅ Important: Take on an empty stomach for better absorption (unlike capsule).
⚠️ Precautions:
- Liver monitoring: LFTs advised during treatment
- Avoid in heart failure patients (black box warning)
- Caution with drug interactions (CYP3A4 inhibitor)
- Avoid simultaneous use with antacids or proton-pump inhibitors
- Not for use in pregnancy
🚫 Contraindications:
- Known hypersensitivity
- Concurrent use with:
- Cisapride, pimozide, quinidine
- Certain statins (simvastatin, lovastatin)
- Congestive heart failure
- Pregnancy (unless life-threatening infection)
💥 Side Effects:
- Nausea, vomiting, diarrhea
- Headache
- Elevated liver enzymes
- Taste disturbance
- Skin rash
- Rare: Hepatitis, hepatotoxicity, edema, arrhythmia
📌 Special Notes:
- Do not interchange with capsule – bioavailability and absorption are different
- Oral liquid is preferred over capsules in candidiasis
- Shake well before use
- Store at room temperature; do not refrigerate