💊 Acetylsalicylic Acid (Aspirin) Tablet 300 mg – 500 mg
📘 Description:
Acetylsalicylic Acid (ASA), commonly known as Aspirin, is a non-steroidal anti-inflammatory drug (NSAID) with analgesic, antipyretic, anti-inflammatory, and antiplatelet properties. The 300 mg to 500 mg dosage is commonly used for pain relief, fever, and inflammation, while lower doses (e.g., 75–100 mg) are used for cardiovascular protection.
🔬 Formulation:
- Active Ingredient: Acetylsalicylic Acid (Aspirin)
- Strength: 300 mg or 500 mg per tablet
- Form: Oral tablet (chewable, enteric-coated, dispersible or plain)
- Route: Oral
🧪 Nature / Mechanism of Action:
- Drug class: NSAID; Salicylate
- Mechanism:
- Irreversibly inhibits cyclooxygenase (COX-1 and COX-2) → ↓ prostaglandin synthesis
- Blocks formation of thromboxane A2 → inhibits platelet aggregation
🩺 Therapeutic Uses / Indications:
| Dose | Indications |
|---|---|
| 300–500 mg | – Mild to moderate pain (e.g., headache, muscle aches, toothache) – Fever due to infections – Inflammatory conditions like arthritis |
| Higher dose (with caution) | – Acute rheumatic fever (as part of anti-inflammatory treatment) – Pericarditis (with other meds) |
| Other indications (lower dose) | – Cardiovascular protection (75–100 mg/day) – not typically 300–500 mg |
✅ Advantages:
- Well-studied, broad utility
- Dual role: Pain + platelet inhibition
- Fast-acting for fever and pain
- Inexpensive and widely available
- Can be used in emergency MI (chewable 300 mg tablet)
⚠️ Precautions:
- Avoid in children <12 years with viral fever (⚠️ Reye’s syndrome risk)
- Avoid in patients with:
- Peptic ulcer disease
- Bleeding disorders
- Aspirin allergy / NSAID sensitivity
- Severe liver or kidney impairment
- Caution in pregnancy (especially 3rd trimester)
📏 Typical Adult Dosing:
- For pain or fever:
🔹 300–600 mg every 4–6 hours, max 4 g/day - Acute MI or Stroke:
🔹 300 mg chewable immediately, followed by low-dose maintenance - Inflammatory conditions:
🔹 Up to 3–4 g/day, in divided doses (only under supervision)
💊 Dosage Forms Available:
- Plain tablets (300 mg, 500 mg)
- Enteric-coated tablets
- Chewable tablets
- Dispersible tablets
- Powder/granules for reconstitution
📦 Storage:
- Store in a cool, dry place (below 25°C)
- Protect from moisture and light
- Keep away from children