Here is a full leaflet-style description of Methylergometrine Injection 0.2 mg/mL, without brand names:
💉 Methylergometrine Injection 0.2 mg/mL
✅ DESCRIPTION
Methylergometrine is a semi-synthetic ergot alkaloid used to prevent and treat postpartum hemorrhage (PPH) by causing sustained uterine contractions. The injectable form is rapid-acting and is often used in labor wards and emergency settings.
🧪 FORMULATION
- Active Ingredient: Methylergometrine maleate 0.2 mg/mL
- Dosage Form: Sterile aqueous solution for injection
- Route of Administration: Intramuscular (IM) or slow Intravenous (IV)
- Ampoule Volume: Usually 1 mL (0.2 mg)
🌿 NATURE
- Type: Uterotonic agent
- Pharmacological Class: Ergot derivative
- Mechanism of Action:
Stimulates alpha-adrenergic receptors and serotonin receptors on uterine smooth muscle, leading to sustained tonic uterine contractions → helps control uterine bleeding
💊 USES
- Primary Indications:
- Treatment and prevention of postpartum hemorrhage (PPH)
- Management of uterine atony post-delivery
- Facilitate expulsion of retained placenta (under medical supervision)
- Supportive Use In:
- After cesarean section (to contract uterus)
- Post-abortion hemorrhage
🌟 ADVANTAGES
- Fast onset: Within 2–5 minutes (IM), ~1 minute (IV)
- Effective in emergencies to rapidly control bleeding
- Longer duration than oxytocin
- Can be combined with oxytocin in some cases (under monitoring)
⚠️ PRECAUTIONS
Contraindications:
- Hypertension, preeclampsia, eclampsia
- Coronary artery disease, peripheral vascular disease
- Severe hepatic or renal dysfunction
- Hypersensitivity to ergot alkaloids
Common Side Effects:
- Nausea, vomiting
- Abdominal cramping
- Elevated blood pressure
- Headache, dizziness
Serious Risks:
- Hypertensive crisis
- Myocardial infarction or stroke (rare but serious)
- Vasoconstriction of limbs or brain vessels
Caution:
- Administer IV slowly over 1 minute to avoid sudden hypertension
- Monitor blood pressure and heart rate continuously
- Avoid use with other vasoconstrictive agents
📅 DOSAGE (Adult)
- IM or slow IV: 0.2 mg (1 mL) after delivery of the anterior shoulder or placenta
- May be repeated every 2–4 hours if needed (max 5 doses/day)
(Always under medical supervision)
🧊 STORAGE
- Store between 2°C and 8°C (refrigerated)
- Protect from light
- Do not freeze
- Use immediately once ampoule is opened
- Discard if solution is discolored or contains particles