Here is the detailed clinical profile for:
💧 Water for Injection (WFI) – Injection
✅ DESCRIPTION
Water for Injection (WFI) is a sterile, non-pyrogenic, and clear preparation of water intended for dilution or reconstitution of parenteral drugs. It contains no active pharmaceutical ingredient or added substances.
⚖️ COMPOSITION
- Water: 100% purified, sterile
- No preservatives, no solutes, no antimicrobial agents
🌿 NATURE
- Isotonicity: Not isotonic by itself
- pH: Typically 5.5–7.0
- Used only after mixing with a compatible drug/solute
- Sterility is ensured until opened
📌 USES
- Reconstitution of dry injectable medications (e.g., antibiotics, vaccines, biologics)
- Dilution of concentrated solutions for IV, IM, or SC use
- Vehicle for small-volume injections
- In compounding settings (hospitals/pharmacies)
🌟 ADVANTAGES
- Safe and non-toxic when used properly
- Ensures accurate reconstitution of critical injectables
- Free from pyrogens (prevents febrile reactions)
⚠️ PRECAUTIONS
- Never use WFI alone IV → Can cause hemolysis due to hypotonicity
- Always mix with a solute before IV administration
- Once opened, use immediately to prevent contamination
- Check for compatibility with the drug being reconstituted
❌ CONTRAINDICATIONS
- Direct IV injection without additives
- Use in large volumes alone
- Not intended for inhalation, oral, or ophthalmic use
💢 SIDE EFFECTS (if misused)
- Hemolysis if given IV without solutes
- Infection risk if aseptic conditions are not followed
- Electrolyte imbalance in large-volume errors
📦 PACKING
- Ampoules: 2 mL, 5 mL, 10 mL
- Vials: 20 mL, 50 mL
- Larger volumes (100–500 mL) for hospital/pharmacy use
🧊 STORAGE
- Store at 15–30°C (room temperature)
- Protect from light
- Use immediately after opening
- Do not use if discolored or particulate matter seen