💊 Tramadol Capsule 100 mg
📘 Description:
Tramadol 100 mg Capsule is a centrally acting opioid analgesic used to treat moderate to severe pain. It is a synthetic derivative of codeine and works by affecting how the brain perceives pain through mu-opioid receptor agonism and monoamine reuptake inhibition (serotonin & norepinephrine).
🔬 Nature / Pharmacologic Class:
- Class: Opioid analgesic (Schedule H / Controlled Drug)
- Type: Centrally acting analgesic
- Mechanism of Action:
- Binds to μ-opioid receptors
- Inhibits reuptake of serotonin and norepinephrine, enhancing pain modulation
🩺 Prescription / Uses:
| Indication | Details |
|---|---|
| Moderate to severe acute pain | Post-operative, trauma, musculoskeletal |
| Chronic pain | Osteoarthritis, cancer, neuropathy |
| Alternative to NSAIDs | In patients with gastric or renal issues |
| Pain unresponsive to non-opioids | When paracetamol/NSAIDs are insufficient |
✅ Advantages:
- Effective in moderate to severe pain
- Dual action: opioid + non-opioid mechanism
- Less respiratory depression compared to morphine
- Available in multiple forms (capsule, injection, SR tablets)
⚠️ Precautions:
- Use cautiously in patients with:
- Seizure disorders
- Respiratory insufficiency
- Hepatic or renal impairment
- Not recommended in children under 12 or postoperative pain in children
- Risk of dependence, especially with prolonged use
- Avoid alcohol, other CNS depressants, and certain antidepressants
📦 Storage & Handling:
- Store below 25°C, away from moisture
- Keep out of reach of children
- Schedule H drug – dispense only with prescription