Here is the detailed pharmaceutical profile for:
💉 Thiamine Injection 100 mg/mL
(Vitamin B1 for parenteral use)
✅ DESCRIPTION
Thiamine (Vitamin B1) injection is a water-soluble vitamin preparation, used to rapidly correct acute or severe thiamine deficiency. It plays a vital role in carbohydrate metabolism, neural conduction, and energy production.
⚖️ COMPOSITION
- Each 1 mL ampoule contains:
- Thiamine hydrochloride … 100 mg
- Water for injection … q.s.
- May contain stabilizers (like sodium metabisulfite)
🧪 NATURE
- Clear, colorless to pale yellow sterile solution
- Administered by intramuscular (IM) or slow intravenous (IV) injection
📌 USES
- Emergency treatment of:
- Wernicke’s encephalopathy
- Alcoholic Korsakoff’s syndrome
- Beri-beri (dry/wet)
- Thiamine deficiency with coma or shock
- Delirium in chronic alcohol use
- Supportive in patients with:
- Prolonged vomiting (e.g., hyperemesis gravidarum)
- Chronic malnutrition
- Hemodialysis, HIV/AIDS, or cancer
🌟 ADVANTAGES
- Rapid onset of action
- Effective for acute neurological conditions
- Avoids need for gut absorption (ideal for vomiting or GI disorders)
⚠️ PRECAUTIONS
- Must be administered slowly IV (rapid injection may cause hypotension)
- Monitor for anaphylaxis, especially in IV use
- Avoid in patients with known sulfite sensitivity (if present)
❌ CONTRAINDICATIONS
- Hypersensitivity to thiamine or formulation components
- Use with caution in sulfite-allergic individuals (check label)
💢 SIDE EFFECTS (rare)
- Local irritation or pain at injection site
- Hypersensitivity reactions (rash, itching)
- Rare but serious:
- Anaphylaxis
- Respiratory distress (especially with IV bolus)
💊 DOSAGE & ADMINISTRATION
- Adults (typical):
- 100–200 mg IV or IM once daily or as directed
- Severe Wernicke’s: up to 500 mg IV TID for 2–3 days
- Followed by oral therapy after stabilization
📦 PACKING
- 1 mL or 2 mL ampoules
- Packed in boxes of 5 or 10 ampoules
🧊 STORAGE
- Store at below 25°C
- Protect from light
- Do not freeze
- Use immediately after opening