Here is the detailed overview of Tenecteplase Injection 40 mg/vial with icons:
💉 Tenecteplase Injection 40 mg/vial
🧪 Nature / Drug Class
🔹 Thrombolytic agent
🔹 Recombinant tissue plasminogen activator (rtPA)
🔹 Acts by converting plasminogen to plasmin – dissolves fibrin clots
🔹 High fibrin specificity
🩺 Purpose / Indications
✅ Used in emergency care for:
- ❤️ Acute ST-Elevation Myocardial Infarction (STEMI) – to restore coronary blood flow
- 🫁 (Off-label/critical care) Massive Pulmonary Embolism (PE)
- 🧠 (Off-label) Acute ischemic stroke in selected cases
⚙️ Advantages
✔️ Single IV bolus dose – simpler and faster than alteplase infusion
✔️ Weight-based dosing – allows precise administration
✔️ Short half-life, rapid onset of action
✔️ Lower risk of systemic bleeding vs. older agents
📦 Common Packaging
📦 Vial: 40 mg lyophilized powder
💧 Supplied with sterile water for reconstitution
💉 For IV bolus injection only
💊 Also available in 30 mg and 50 mg vial strengths for weight-based dosing
⚠️ Patient Advice / Precautions
🕐 Administer within 6 hours of symptom onset in MI (preferably within 3 hours)
🩸 Monitor for bleeding, especially intracranial hemorrhage
📉 Check baseline BP, CBC, PT/INR, aPTT
🧠 Avoid IM injections or invasive procedures post-dose
⚠️ Not for repeated use or prophylaxis
🚫 Contraindications
❌ Active internal bleeding
❌ History of intracranial hemorrhage or stroke
❌ Recent brain/spinal surgery or trauma
❌ Uncontrolled hypertension (>180/110 mmHg)
❌ Known bleeding diathesis
🧊 Storage
🌡️ Store below 25°C (do not freeze)
💧 After reconstitution, use immediately or within 8 hours (if refrigerated 2–8°C)
🧒 Keep away from children