Here is the complete information for Tenecteplase Injection 40 mg/vial:
💉 Tenecteplase – Injection 40 mg/vial
🔹 Description:
Tenecteplase is a recombinant tissue plasminogen activator (rt-PA) used as a thrombolytic agent. It breaks down clots in blood vessels and is primarily used in emergency cardiac care.
🔬 Nature / Drug Class:
- Nature: Biologic thrombolytic agent
- Drug Class: Fibrinolytic / Plasminogen activator (rDNA origin)
🎯 Purpose / Indications:
- Treatment of acute ST-elevation myocardial infarction (STEMI)
- Administered as soon as possible within 6 hours of symptom onset
- Helps restore blood flow by dissolving clots in coronary arteries
✅ Advantages:
- Single bolus IV injection – enables rapid administration
- Higher fibrin specificity – targets clots more precisely
- Longer half-life – allows for one-time dosing, reducing need for infusion
- Reduced need for prolonged monitoring compared to alteplase
📦 Common Packaging:
- Supplied as lyophilized powder in 40 mg vial
- Accompanied by sterile water for injection (for reconstitution)
- Often packed in kits with syringe, transfer cannula
- Must be stored in refrigerated conditions (2–8°C)
- Do not freeze
⚠️ Patient Advice / Precautions:
- Hospital use only, under supervision of experienced physicians
- Monitor for:
- Bleeding, especially internal or cerebral
- Allergic reactions, hypotension, or arrhythmia
- Contraindicated in:
- Active bleeding or history of hemorrhagic stroke
- Recent surgery, trauma, or uncontrolled hypertension
- Handle reconstitution gently (no vigorous shaking)
- Ensure renal, liver, and coagulation parameters are reviewed pre-administration