Here is the detailed overview of Sodium Valproate Tablet 300 mg (brand-free format):
💊 Sodium Valproate Tablet 300 mg
✅ DESCRIPTION
Sodium Valproate 300 mg is an oral anticonvulsant and mood stabilizer. It is commonly used to treat epilepsy, bipolar disorder, and migraine prevention. The drug acts primarily by enhancing GABA activity, which stabilizes electrical nerve activity in the brain.
🧪 FORMULATION
- Active Ingredient: Sodium Valproate 300 mg
- Dosage Form: Oral tablet (may be enteric-coated or modified-release)
- Route: Oral
- Common Excipients: Lactose, starch, magnesium stearate, cellulose derivatives, coating polymers (varies by formulation)
🌿 NATURE
- Type: Anticonvulsant, mood stabilizer
- Class: Fatty acid derivative
- Mechanism of Action:
- Increases GABA concentrations by inhibiting GABA transaminase
- Modifies sodium and calcium ion channels
- Stabilizes neuronal firing and reduces excitability
💡 USES
- Epilepsy
- Generalized tonic-clonic seizures
- Absence seizures
- Myoclonic and partial seizures
- Bipolar Disorder
- Management of acute manic episodes
- Long-term mood stabilization
- Migraine Prophylaxis
- Reduces frequency and intensity of migraine attacks
🌟 ADVANTAGES
- Suitable for a wide spectrum of seizure types
- Intermediate strength (300 mg) allows for flexible dose adjustment
- Available in sustained-release or enteric-coated versions for tolerability
- Effective in neuropsychiatric and neurological indications
- Useful as monotherapy or in combination with other drugs
⚠️ PRECAUTIONS
Common Side Effects:
- Nausea, gastric upset
- Drowsiness, fatigue
- Weight gain
- Hair loss (reversible)
- Tremors
- Menstrual disturbances
Serious Risks:
- Hepatotoxicity (especially in children under 2)
- Pancreatitis
- Thrombocytopenia (low platelet count)
- Hyperammonemia
- Risk of birth defects in pregnancy (neural tube defects, cognitive impairment)
Contraindications:
- Liver disease
- Known hypersensitivity to valproate
- Pregnancy (unless essential)
- Urea cycle disorders
Monitoring:
- Liver function tests (LFT) before and during treatment
- CBC with platelets
- Serum valproate level: Target range 50–100 mcg/mL
- Monitor for signs of sedation, confusion, or tremor
🧊 STORAGE
- Store at 15°C to 30°C (room temperature)
- Keep away from heat, moisture, and direct sunlight
- Do not freeze
- Store in original blister pack or container
- Keep out of reach of children