Here is a detailed brand-free overview of Sodium Valproate Tablet 200 mg:
💊 Sodium Valproate Tablet 200 mg
✅ DESCRIPTION
Sodium Valproate 200 mg is an antiepileptic drug (AED) and mood stabilizer used to treat various types of seizures and bipolar disorder. It works by increasing gamma-aminobutyric acid (GABA) levels in the brain, which calms nerve activity and reduces abnormal brain signals.
🧪 FORMULATION
- Active Ingredient: Sodium Valproate – 200 mg per tablet
- Dosage Form: Oral tablet (may be enteric-coated)
- Route of Administration: Oral
🌿 NATURE
- Pharmacological Class: Anticonvulsant / Mood stabilizer
- Mechanism of Action:
- Increases GABA in the brain
- Inhibits voltage-gated sodium channels
- Reduces neuronal excitability and abnormal discharges
💡 USES
✅ Therapeutic Indications:
- Epilepsy:
- Generalized tonic-clonic seizures
- Absence seizures
- Myoclonic seizures
- Partial seizures
- Bipolar disorder:
- Treatment and prevention of manic episodes
- Migraine prophylaxis
🌟 ADVANTAGES
- Broad-spectrum antiepileptic effective in multiple seizure types
- Well-established mood stabilizer
- Useful in mixed or rapid-cycling bipolar states
- Oral administration allows for outpatient use
- Available in multiple dosage forms for titration
⚠️ PRECAUTIONS
🔸 Common Side Effects:
- Nausea, vomiting
- Tremor, weight gain
- Hair thinning or loss
- Sleepiness or dizziness
🔹 Serious Risks:
- Hepatotoxicity (especially in young children)
- Pancreatitis
- Thrombocytopenia (low platelets)
- Hyperammonemia
- Teratogenicity (avoid in pregnancy due to risk of neural tube defects)
🚫 Contraindications:
- Known liver disease or significant hepatic dysfunction
- Urea cycle disorders
- Pregnancy (especially for migraine or bipolar indications)
- Hypersensitivity to valproate
⚠️ Monitoring:
- Liver function tests (especially in first 6 months)
- CBC (platelets)
- Serum valproate levels (therapeutic range: 50–100 µg/mL)
- Monitor for signs of liver failure, bleeding, or pancreatitis
🧊 STORAGE
- Store at room temperature (15–30°C)
- Protect from moisture and light
- Keep in tightly closed container
- Keep out of reach of children