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✅ 1. Description / Prescription
- Generic Name: Sodium Valproate (Modified Release)
- Strength: 500 mg
- Dosage Form: Oral Tablet (Modified Release)
- Route: Oral
- Prescription Required: ✔️ Yes
- Indications:
- Treatment of epilepsy (all types of seizures)
- Maintenance therapy for bipolar disorder
- Migraine prophylaxis in select cases
✅ 2. Nature of the Medicine
- Therapeutic Class: Anticonvulsant / Mood Stabilizer
- Formulation: Modified Release (MR) or Controlled Release (CR)
- Mechanism of Action:
- Increases GABA activity in the brain (inhibitory neurotransmitter)
- Reduces abnormal electrical discharges by affecting sodium and calcium channels
✅ 3. Advantages
- Once or twice-daily dosing due to slow, sustained drug release
- Maintains more stable blood levels – fewer side effects and better control
- Helps avoid sharp peaks in drug concentration (reduces sedation, nausea)
- Convenient for long-term therapy
- Especially useful for patients with poor adherence to frequent dosing
✅ 4. Common Packaging
- Tablet Type: Film-coated or enteric-coated, oval or capsule-shaped
- Typical Labels:
- “Sodium Valproate MR 500 mg”
- Or brand names like Valparin Chrono 500, Epilim Chrono 500
- Packaging: Blister strips of 10 or 15 tablets, or bottles
✅ 5. Storage Conditions
- Temperature: Store below 25°C
- Keep away from: Moisture, heat, and direct sunlight
- Packaging: Store in original packaging; do not break open unless about to use
✅ 6. Patient Advice
- Take with or after food to reduce stomach upset
- Swallow whole — do not crush, break, or chew MR tablets
- Take at the same time(s) daily for consistent blood levels
- Do not stop medication suddenly – may cause seizure recurrence
- Avoid alcohol or sedatives unless approved by your doctor
- Regular liver function and blood tests may be needed during treatment
- Pregnancy Warning:
- Sodium valproate can cause severe birth defects and developmental disorders
- Use strict contraception if you are of childbearing age
- Do not use during pregnancy unless absolutely necessary and monitored closely
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