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✅ 1. Description / Prescription
- Generic Name: Sodium Valproate (Modified Release)
- Dosage Form: Oral Tablet
- Strength: 300 mg
- Route of Administration: Oral
- Prescription Required: ✔️ Yes
- Indications:
- Epilepsy (generalized, partial, and mixed seizures)
- Bipolar disorder (maintenance treatment)
- Migraine prophylaxis
✅ 2. Nature of the Medicine
- Class: Anticonvulsant / Antiepileptic / Mood stabilizer
- Formulation:Modified Release (MR)
- Also known as Controlled Release (CR) or Extended Release (ER)
- Designed to release the drug slowly over time, allowing for fewer daily doses
- Mechanism of Action:
- Increases GABA (an inhibitory neurotransmitter) in the brain
- Stabilizes overactive nerve signals by modulating sodium and calcium channels
✅ 3. Advantages
- Longer duration of action than regular tablets
- Often allows for once or twice daily dosing
- Reduces peak-trough fluctuations in blood levels, improving seizure control
- May cause fewer gastrointestinal side effects compared to immediate-release tablets
- Convenient for long-term management of epilepsy or bipolar disorder
✅ 4. Common Packaging
- Tablet Form: Film-coated or enteric-coated
- Labeling: Often marked as “Sodium Valproate MR 300 mg” or brand variants (e.g., Valparin Chrono 300, Epilim Chrono 300)
- Pack Size: Usually in blister strips of 10 or 15 tablets
✅ 5. Storage Conditions
- Temperature: Store below 25°C
- Keep away from: Heat, moisture, and direct sunlight
- Packaging: Keep in original packaging; do not remove until use
✅ 6. Patient Advice
- Take with food to reduce the chance of gastric upset
- Swallow whole — do not chew, crush, or break the tablet
- Maintain a consistent dosing schedule every day
- Do not stop the medicine suddenly — risk of seizure relapse
- Inform your doctor before using any new medications, especially CNS depressants
- Women of childbearing age:
- Use effective contraception
- Valproate is teratogenic (can harm unborn babies) — use only if no alternative works
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