Here is a detailed overview of:
💉 Ranitidine Injection 25 mg/mL
🧪 Nature / Drug Class
🔹 H2-receptor antagonist
🔹 Suppresses gastric acid secretion by blocking histamine at H2 receptors on parietal cells
🩺 Purpose / Indications
✅ Used in:
- Acute duodenal/gastric ulcer management
- Gastroesophageal reflux (GERD) in hospitalized patients
- Prophylaxis and treatment of stress ulcers
- Upper GI bleeding (as adjunct therapy)
- Zollinger-Ellison syndrome
- When oral therapy is not possible
⚙️ Advantages
✔️ Rapid onset of action
✔️ Suitable for emergency and critical care use
✔️ IV/IM routes allow controlled dosing
✔️ Useful for NPO (nothing by mouth) patients
💉 Dosage & Administration
- IV slow injection: 50 mg (2 mL) diluted in 20 mL of 0.9% saline over at least 5 minutes
- IV infusion: 25 mg/mL diluted as per protocol
- IM injection: Undiluted, 50 mg (2 mL)
- Dosing frequency: Every 6–8 hours, or as continuous infusion in ICU
📦 Common Packaging
📦 2 mL ampoules or vials (i.e., 50 mg)
💉 Concentration: 25 mg/mL
🧴 For IV/IM administration
⚠️ Patient Advice / Precautions
❗ Use with caution in renal impairment – dose adjustment needed
📛 Monitor for rare side effects: arrhythmias, bradycardia, liver enzyme elevation
🧪 Should not be mixed with incompatible IV drugs in the same line
⚠️ Regulatory Warning: Withdrawn or restricted in many countries due to NDMA impurity risk
📋 Use only under medical supervision and when clearly indicated
🧊 Storage
🌡 Store at room temperature (15–25°C)
🧫 Protect from light
🧯 Do not freeze