Primaquine Tablet 15 mg

📌 Description:

1. Primaquine is an antimalarial medication belonging to the 8-aminoquinoline class.
2. Each tablet typically contains 15 mg of primaquine phosphate, equivalent to about 13.2 mg of primaquine base.
3. It is primarily effective against exoerythrocytic (liver) stages of Plasmodium parasites.
4. It appears as a film-coated, light-colored tablet, and may have a slight medicinal odor.
5. It is prescribed after initial treatment to prevent relapse of malaria caused by P. vivax and P. ovale.

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🧪 Nature:

1. Synthetic antimalarial agent, derived from 8-aminoquinoline structure.
2. Acts as a tissue schizonticide targeting hypnozoites in liver cells.
3. Also exhibits gametocytocidal activity against P. falciparum.
4. Water-soluble and undergoes hepatic metabolism.
5. Possesses oxidative properties, hence caution is needed in G6PD-deficient individuals.

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💡 Advantages:

1. Eradicates dormant liver stages (hypnozoites) of P. vivax/P. ovale, reducing relapses.
2. Only drug effective for radical cure of relapsing malaria.
3. Helps in interrupting transmission by killing P. falciparum gametocytes.
4. Short course therapy when used in combination with chloroquine or ACTs.
5. Has a role in malaria elimination programs globally.

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💊 Uses:

1. Treatment of relapsing malaria caused by Plasmodium vivax and Plasmodium ovale.
2. Used to eliminate gametocytes of P. falciparum to prevent further spread.
3. May be used as part of chemoprophylaxis in specific cases.
4. Often administered after initial treatment with chloroquine or ACT to ensure radical cure.
5. Occasionally studied for use in leishmaniasis (off-label use).

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🏥 Storage:

1. Store in a cool, dry place, ideally between 15–25°C (59–77°F).
2. Keep away from light and moisture to preserve stability.
3. Store in the original container tightly closed.
4. Keep out of reach of children, as overdose can be harmful.
5. Do not use beyond expiration date; discard unused tablets properly.

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