Here is the full product profile for:
💉 Piperacillin 4000 mg + Tazobactam 500 mg Powder for Injection
📘 Description:
This is a combination broad-spectrum antibiotic injection containing:
- Piperacillin (4 g / 4000 mg) – A penicillin-type antibiotic
- Tazobactam (0.5 g / 500 mg) – A β-lactamase inhibitor
Supplied as a sterile lyophilized powder, for intravenous (IV) infusion after reconstitution.
💊 Prescription / Indications:
Used for moderate to severe systemic bacterial infections, including:
- Hospital-acquired pneumonia (HAP), including ventilator-associated pneumonia (VAP)
- Intra-abdominal infections (e.g., peritonitis)
- Complicated urinary tract infections (cUTI)
- Skin and soft tissue infections (including diabetic foot)
- Febrile neutropenia (empirical therapy)
- Sepsis and bloodstream infections
- Pelvic infections
🩺 Uses:
- Empiric treatment for mixed or resistant bacterial infections
- Often used in ICU settings or post-operative infections
- Especially effective against Pseudomonas aeruginosa
🌿 Nature / Drug Class:
- Piperacillin: Extended-spectrum β-lactam (ureidopenicillin)
- Tazobactam: β-lactamase inhibitor
- Class: Penicillin antibiotic combination
- Route: Intravenous use only
✅ Advantages:
- Broad antibacterial coverage, including β-lactamase-producing organisms
- Effective in mixed aerobic/anaerobic infections
- Used in critical care and empirical therapies
- Covers Gram-positive, Gram-negative, and some anaerobes
- Pseudomonas coverage makes it key in serious nosocomial infections
⚠️ Precautions:
- Contraindicated in patients with penicillin allergy
- Monitor:
- Renal function (especially in elderly or critically ill)
- Electrolytes (especially potassium and sodium)
- Liver enzymes and blood counts with prolonged use
- Adjust dose in renal impairment
- Possible adverse effects:
- Rash, nausea, diarrhea
- Thrombophlebitis
- Electrolyte imbalance
- Rare: Seizures, C. difficile-associated diarrhea
📦 Common Packaging:
- Vial containing 4.5 g powder for reconstitution, with:
- Piperacillin 4000 mg
- Tazobactam 500 mg
- Supplied in single-use glass vials
- Requires dilution with sterile water or saline
- Administered via slow IV infusion (20–30 minutes)
❄️ Storage:
- Store at 15–25°C in a dry place
- Protect from light and moisture
- After reconstitution:
- Use immediately or refrigerate (2–8°C)
- Stable for up to 24 hours refrigerated
- Do not freeze the reconstituted solution