Here is a detailed profile for:
💉 Piperacillin 1000 mg + Tazobactam 125 mg Powder for Injection
📘 Description:
This is a fixed-dose combination injectable antibiotic containing:
- Piperacillin (1000 mg): a broad-spectrum ureidopenicillin
- Tazobactam (125 mg): a β-lactamase inhibitor that protects piperacillin from enzymatic degradation
Supplied as a sterile powder for reconstitution and IV administration.
💊 Prescription / Indications:
Indicated for moderate to severe bacterial infections including:
- Lower respiratory tract infections (e.g. hospital-acquired pneumonia)
- Intra-abdominal infections
- Skin and soft tissue infections
- Urinary tract infections
- Gynecological infections
- Febrile neutropenia (as part of empiric therapy)
- Bone and joint infections
- Sepsis and bacteremia
🩺 Uses:
- Active against Gram-positive, Gram-negative, and anaerobic bacteria
- Covers β-lactamase-producing pathogens
- Often used in hospital settings for serious or resistant infections
- Can be used in adult and pediatric patients (with dose adjustments)
🌿 Nature:
- Drug Class:
- Piperacillin: Antipseudomonal penicillin (β-lactam antibiotic)
- Tazobactam: β-lactamase inhibitor
- Route of Administration: Intravenous (IV) only
- Mechanism: Piperacillin inhibits bacterial cell wall synthesis; Tazobactam inhibits β-lactamases
✅ Advantages:
- Broad-spectrum coverage, including Pseudomonas aeruginosa
- Effective in mixed infections (aerobes + anaerobes)
- Reduced resistance due to tazobactam
- Preferred in empirical therapy for critically ill patients
- Suitable for polymicrobial infections
⚠️ Precautions:
- Contraindicated in patients allergic to penicillins, cephalosporins, or β-lactam antibiotics
- Adjust dose in renal impairment
- Monitor:
- Electrolyte balance (especially sodium levels)
- Liver and kidney function during prolonged therapy
- Signs of superinfection, diarrhea, or C. difficile colitis
- Use in pregnancy only if clearly needed
- Not for IM use (formulation specific)
📦 Common Packaging:
- Glass vial with 1.125 g total content:
- Piperacillin 1000 mg
- Tazobactam 125 mg
- Packaged in single or multiple vial boxes
- To be used with sterile diluent for IV infusion or slow IV injection
❄️ Storage:
- Store below 25°C, protected from moisture
- Reconstituted solution should be used within 24 hours if refrigerated (2–8°C)
- Do not freeze reconstituted product
- Discard unused portions safely