💉 Pheniramine Injection 22.75 mg/mL
📘 Description:
Pheniramine maleate is a first-generation antihistamine (H₁ receptor blocker), commonly used for the treatment of allergic reactions, anaphylaxis adjunct therapy, and inflammatory conditions. It has sedative and anticholinergic effects. The injectable form is typically used in emergency care or when oral administration is not possible.
- Form: Injectable solution (usually IM or slow IV)
- Strength: 22.75 mg/mL
- Route: Intramuscular (IM), Intravenous (slow IV)
- Common Brand Names: Avil®, Avomine® (region-dependent)
🩺 Prescription / Medical Uses:
| Indications | Purpose |
|---|---|
| Anaphylaxis (with adrenaline) | Antihistamine component |
| Urticaria (hives), angioedema | Rapid symptom relief |
| Allergic rhinitis or conjunctivitis (acute) | Short-term control of symptoms |
| Insect bite or drug allergies | Reduces histamine-related symptoms |
| Motion sickness / nausea (off-label) | Anticholinergic & sedative effect |
| Adjunct in cold/cough preparations (injection) | Decongestant aid |
✅ Advantages:
- Rapid onset when given IV or IM
- Effective in acute allergic reactions
- Has sedative and antiemetic properties
- Useful as adjunct with adrenaline and steroids in anaphylaxis
- Often available OTC in oral form; injectable form is prescription-based
⚠️ Precautions:
- Avoid in patients with:
- Severe liver/kidney dysfunction
- Prostatic hypertrophy
- Angle-closure glaucoma
- Epilepsy or seizure disorders
- Caution in elderly (higher sedation risk)
- Not recommended in pregnancy (unless benefit outweighs risk)
🧠 Patient Advice:
- Do not drive or operate machinery after injection
- Avoid alcohol or other sedating medications
- Inform healthcare provider if on antidepressants, sedatives, or muscle relaxants
📦 Storage:
- Store between 15–25°C
- Protect from light and freezing
- Use clear solution only; discard if discolored/cloudy