Paromomycin Injection 375 mg/mL

💊 Paromomycin Injection 375 mg/mL

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📘 Description:

1. Paromomycin is an aminoglycoside antibiotic derived from Streptomyces rimosus.
2. This injection contains 375 mg of paromomycin per mL, usually in a sterile aqueous solution.
3. It is used parenterally (intramuscularly) for the treatment of protozoal and parasitic infections.
4. The solution is typically clear to pale yellow, odorless, and free from visible particles.
5. It acts primarily by binding to 30S ribosomal subunits, inhibiting protein synthesis in pathogens.

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🌿 Nature:

1. Paromomycin is a bactericidal and amebicidal agent of the aminoglycoside class.
2. It has activity against protozoa, cestodes, and some bacteria, especially Entamoeba histolytica.
3. It is not absorbed from the gastrointestinal tract when taken orally but has systemic effects when injected.
4. The injectable form allows systemic delivery, important in visceral infections.
5. It is considered a second-line drug in certain neglected tropical diseases.

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✅ Advantages:

1. Effective alternative in treating visceral leishmaniasis, especially where resistance exists.
2. Intramuscular route ensures reliable systemic delivery in serious infections.
3. Well-tolerated with relatively low systemic toxicity when dosed correctly.
4. Can be used in combination therapies to prevent resistance and enhance efficacy.
5. Useful in resource-limited settings as part of national disease elimination programs.

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🩺 Uses:

1. Treatment of visceral leishmaniasis (Kala-azar), particularly in South Asia and East Africa.
2. As an alternative to amphotericin B or miltefosine in patients with contraindications.
3. May be used in intestinal amebiasis, especially in severe cases needing parenteral therapy.
4. Employed in combination with sodium stibogluconate or miltefosine for better outcomes.
5. Has shown activity against tapeworms and other intestinal parasites in some studies.

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❄️ Storage:

1. Store at 2°C to 8°C (refrigerated) – do not freeze the solution.
2. Keep the vial away from light and maintain in the original carton until use.
3. Discard any unused portion after opening to avoid contamination.
4. Do not use if the solution appears cloudy or contains particulates.
5. Ensure storage is compliant with cold-chain protocols, especially in field settings.

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