💉 Pantoprazole Injection 40 mg – As Licensed
📄 Description:
Pantoprazole Injection 40 mg is a proton pump inhibitor (PPI) used intravenously for short-term treatment of acid-related gastrointestinal conditions when oral administration is not feasible. It suppresses gastric acid secretion by blocking the H⁺/K⁺-ATPase enzyme in gastric parietal cells.
🧾 Prescription / Indications:
Used for the:
- Treatment of gastroesophageal reflux disease (GERD) with erosive esophagitis
- Peptic ulcer disease
- Stress ulcer prophylaxis in ICU patients
- Zollinger–Ellison syndrome and other hypersecretory conditions
- Prevention of re-bleeding in upper gastrointestinal bleeding (with endoscopic therapy)
Typical Adult Dose:
- 40 mg IV once daily, administered over 2 to 15 minutes (as bolus) or by 15-minute infusion
- Dosage may be adjusted based on clinical need
🔬 Nature:
- Class: Proton Pump Inhibitor
- Form: Lyophilized powder or solution for reconstitution
- Route: Intravenous (IV)
🌟 Advantages:
- Rapid acid suppression
- Useful in patients who are NPO (nothing by mouth)
- Reduces risk of aspiration and stress ulcers in critical care
- Can be transitioned to oral therapy once patient stabilizes
📦 Packaging:
- Vial containing 40 mg pantoprazole sodium (as lyophilized powder)
- Usually provided with ampoule of normal saline for reconstitution or mixed with 5–10 mL of saline before IV push
- Comes in single-use vials (glass)
🧊 Storage:
- Store below 25°C, protect from light and moisture
- Do not freeze reconstituted solution
- Use immediately after reconstitution (within 12 hours if refrigerated and stable)
⚠️ Precautions:
- Use with caution in:
- Hepatic impairment
- Osteoporosis or fracture risk (long-term use)
- Patients on high-dose or prolonged therapy
- May alter absorption of:
- Vitamin B12
- Iron
- Antifungal agents
- May cause:
- Hypomagnesemia
- Headache, dizziness, rash
- Monitor liver enzymes during long-term use
👩⚕️ Patient Advice:
- This injection is for hospital/clinical use only
- You may be switched to oral pantoprazole once you’re stable
- Inform your provider if you have:
- Liver problems
- Low magnesium or calcium
- Are on blood thinners (warfarin) or antivirals
- Report symptoms like:
- Muscle cramps
- Seizures
- Palpitations