đź’‰ DESCRIPTION
Paclitaxel T Injection 100 mg/16.7 mL is a concentrated solution for intravenous infusion. It is a plant-derived antineoplastic agent obtained from the bark of the Pacific yew tree (Taxus brevifolia) and belongs to the taxane class of chemotherapeutic agents.
- Generic Name: Paclitaxel
- Strength: 100 mg per 16.7 mL (i.e., 6 mg/mL)
- Form: Concentrated solution for injection
- Route: IV infusion after dilution
- Common Brands: Taxol®, Onxol®, Paclitaxel T®, Paxet®
- Therapeutic Class: Cytotoxic – Taxane (mitotic inhibitor)
âś… ADVANTAGES
- Active against multiple cancers: breast, ovarian, non-small cell lung cancer (NSCLC), Kaposi’s sarcoma
- Useful in both adjuvant and metastatic settings
- Synergistic with platinum agents (cisplatin/carboplatin)
- Established standard in many chemotherapy protocols
- Effective in taxane-sensitive tumors even after anthracycline failure
🌿 NATURE / MECHANISM OF ACTION
- Paclitaxel stabilizes microtubules and inhibits their disassembly, interfering with the normal breakdown of microtubules during cell division.
- Arrests the cell cycle in the G2/M phase, inhibiting mitosis and causing apoptosis.
- Particularly effective against rapidly dividing tumor cells.
⚠️ PRECAUTIONS
- Requires premedication to prevent severe hypersensitivity reactions, which may be caused by Cremophor EL (polyoxyethylated castor oil):
- Dexamethasone
- Diphenhydramine
- Ranitidine or H2 antagonist
- Myelosuppression (especially neutropenia) is dose-limiting
- Peripheral neuropathy may occur, especially at higher cumulative doses
- Avoid use in patients with significant hepatic impairment
- Do not use PVC containers or tubing (Cremophor leaches DEHP)
- Monitor for cardiac effects (bradycardia, hypotension, ECG changes)
🧊 STORAGE
- Store at 20–25°C (controlled room temperature)
- Do not refrigerate or freeze
- Protect from light and heat
- Stable for up to 27 hours after dilution at room temperature (per product-specific data)
- Always check for precipitation or cloudiness before administration
👨‍⚕️ PATIENT ADVICE
- Inform about potential hair loss, numbness, tingling, or mouth sores
- Avoid cold drinks and exposure if experiencing neuropathy
- Use effective contraception during and at least 6 months after treatment
- Avoid live vaccines during treatment
- Maintain hydration and report signs of infection or bleeding
- Attend all scheduled blood tests (CBC, liver enzymes)
📦 PACKAGING
- Amber-colored glass vial
- Contains 16.7 mL of solution (100 mg of paclitaxel at 6 mg/mL)
- Rubber stopper and aluminum cap with flip-off seal
- Labeled with:
- Strength, volume, batch number, expiry
- Storage conditions
- “Cytotoxic – Handle with care” warning
- Supplied in carton box with package insert