Here is a complete overview of Nicotine 2 mg (Oral dosage forms) — no brand names included:
💊 Nicotine 2 mg (Oral Dosage Forms)
(Commonly available as gums, lozenges, or oral dissolvable films)
✅ DESCRIPTION
Nicotine in oral form is a nicotine replacement therapy (NRT) used to help people quit smoking or reduce tobacco dependence by supplying controlled doses of nicotine without the harmful effects of tobacco smoke.
🧪 FORMULATION
- Nicotine Polacrilex equivalent to 2 mg nicotine per unit
- Available as:
- Chewing gum
- Lozenges
- Oral films or strips
🌿 NATURE
- Class: Smoking cessation aid
- Type: Systemic stimulant (cholinergic agonist)
- Mechanism: Stimulates nicotinic receptors, reducing cravings and withdrawal symptoms
📌 USES
- Aid for smoking cessation
- Reduce withdrawal symptoms during tobacco quitting
- Used as part of step-down nicotine therapy
🌟 ADVANTAGES
- Reduces cravings without tobacco
- Avoids tar, carbon monoxide, and carcinogens from cigarettes
- Easy oral route, self-administered
- Helps in gradual nicotine tapering
- May be combined with behavioral therapy
⚠️ PRECAUTIONS
Side Effects:
- Mouth soreness, hiccups, throat irritation
- Heartburn, nausea, jaw pain (with gum)
- Sleep disturbances, dizziness
Warnings:
- Use with caution in cardiovascular disease (recent MI, arrhythmias)
- Avoid in patients with TMJ disorders (gum)
- Not ideal for pregnant or breastfeeding women unless advised by a doctor
❌ CONTRAINDICATIONS
- Allergy to nicotine or excipients
- Non-smokers or occasional smokers
- Children under 18 unless prescribed
⚕️ INSTRUCTIONS FOR USE
For Nicotine Gum:
- Chew slowly until peppery taste appears
- “Park” between cheek and gum
- Repeat chewing every few minutes for ~30 minutes
- Avoid food/drink 15 minutes before and after use
For Lozenges:
- Place in mouth and allow to dissolve slowly
- Move from side to side, do not chew/swallow
🔁 DOSAGE GUIDANCE
- Light smokers (≤10 cigarettes/day) → Start with 2 mg
- Use 1 piece every 1–2 hours, up to 9–12 per day
- Gradually reduce over 12 weeks
- Max: 24 pieces/day (gum); 20 per day (lozenges)
🤝 DRUG INTERACTIONS
- May alter effects of medications metabolized via CYP1A2, like:
- Theophylline
- Caffeine
- Insulin
- Beta-blockers
- Smoking cessation may change drug metabolism
🧊 STORAGE
- Store at room temperature (15–30°C)
- Keep sealed in original blister/packaging
- Avoid moisture and direct sunlight
- Keep out of reach of children and pets