Miltefosine Capsule 50 mg

💊 Miltefosine Capsule 50 mg

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📘 Description:

1. Miltefosine is an oral antileishmanial drug, the first of its kind available in capsule form.
2. Each capsule contains 50 mg of miltefosine, a phospholipid derivative.
3. It is structurally related to phosphocholine and acts by disrupting parasite membrane integrity.
4. The capsule is usually white or off-white, intended for oral administration.
5. Approved for cutaneous, mucocutaneous, and visceral leishmaniasis (Kala-azar).

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🌿 Nature:

1. It is a synthetic alkylphosphocholine compound, originally developed as an anticancer agent.
2. Acts as a leishmanicidal drug by interfering with lipid metabolism and mitochondrial function.
3. Has immunomodulatory and antiprotozoal properties.
4. Available in oral capsule form, unlike many other antileishmanial drugs which are injectables.
5. Its lipophilic nature allows good absorption and distribution in tissues.

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✅ Advantages:

1. First-line oral treatment for leishmaniasis — no need for injections or hospitalization.
2. Excellent efficacy against Leishmania donovani in both immunocompetent and immunocompromised patients.
3. Simplified logistics in remote areas due to oral administration.
4. Can be used in combination regimens to prevent resistance.
5. Useful in both visceral and cutaneous forms of leishmaniasis.

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🩺 Uses:

1. Treatment of visceral leishmaniasis (Kala-azar) in endemic regions.
2. Used for cutaneous leishmaniasis, including Old World and New World species.
3. Also effective in mucocutaneous leishmaniasis.
4. Sometimes used off-label for free-living amoeba infections (e.g., Naegleria fowleri).
5. Under investigation for potential use in immunosuppressed patients with leishmanial co-infection.

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❄️ Storage:

1. Store capsules at room temperature (15–30°C) in a dry place.
2. Protect from moisture, heat, and direct sunlight.
3. Keep in original packaging until use to ensure product integrity.
4. Ensure child-resistant containers if stored in households.
5. Check expiration date before use and dispose of expired medication properly.