Here is the detailed information for Meropenem Powder for Injection 500 mg (as trihydrate):
๐ Meropenem Powder for Injection 500 mg
๐งช Generic Name:
Meropenem (as trihydrate)
๐ Form & Strength:
- Form: Sterile lyophilized powder for reconstitution
- Strength: 500 mg per vial
- Route: Intravenous (IV) or Intramuscular (IM) use
๐ฆ Packaging:
- Glass vial with rubber stopper and flip-off cap
- Usually packed in:
- Single vials or boxes of 1/10 vials
- Diluent: Sterile water for injection (supplied separately or reconstituted before administration)
- Storage:
- Store below 25ยฐC
- Protect from light and moisture
- Reconstituted solution should be used within specified time (typically within 6 hours at room temp or 24 hours refrigerated)
๐ฌ Pharmacological Class:
- Class: Carbapenem antibiotic
- Broad-spectrum ฮฒ-lactam effective against gram-positive, gram-negative, and anaerobic bacteria
๐ Indications / Uses:
- Intra-abdominal infections
- Meningitis (bacterial)
- Skin and soft tissue infections
- Urinary tract infections
- Lower respiratory tract infections (pneumonia, bronchitis)
- Septicemia
- Febrile neutropenia (as empirical therapy)
๐ Dosage & Administration:
- Adults: 500 mg IV every 8 hours (standard dose)
- Dose can go up to 1g depending on severity/site
- Children (>3 months): 10โ20 mg/kg every 8 hours
- Administer IV over 15โ30 minutes or IM as per guidelines
- Dose adjustment required in renal impairment
โ ๏ธ Precautions:
- Use with caution in renal dysfunction, seizure disorders
- Monitor for superinfection, especially Clostridium difficile-associated diarrhea
โ Contraindications:
- Known hypersensitivity to carbapenems, penicillins, or other ฮฒ-lactams
- Use in neonates <3 months (limited safety data)
๐ฅ Common Side Effects:
- Nausea, vomiting, diarrhea
- Rash or injection site reactions
- Headache
- Seizures (high dose or renal failure)
- Elevated liver enzymes