Here is a complete and easy-to-understand overview of:
💉 Meropenem Powder for Injection 1000 mg (1 g) (as trihydrate)
🌿 Nature / Drug Class:
- Meropenem is a broad-spectrum antibiotic
- Belongs to the Carbapenem group (a subclass of beta-lactam antibiotics)
- Bactericidal – works by inhibiting bacterial cell wall synthesis
🎯 Purpose / Indications:
Used in the treatment of moderate to severe bacterial infections, especially those resistant to other antibiotics:
- Severe pneumonia (including hospital-acquired)
- Complicated urinary tract infections
- Intra-abdominal infections (e.g., appendicitis, peritonitis)
- Skin and soft tissue infections
- Meningitis (especially in children)
- Sepsis / bloodstream infections
- Febrile neutropenia in cancer patients
- Infections caused by multi-drug resistant (MDR) bacteria
✅ Advantages:
- Very broad-spectrum coverage
- Highly effective in ICU and emergency care
- Useful when other antibiotics fail
- Suitable for life-threatening infections
- Rapid response when given IV
💉 Form & Administration:
- Supplied as a dry powder in a vial containing 1 g (1000 mg) Meropenem as trihydrate
- To be reconstituted with sterile water or compatible IV fluid (e.g., 0.9% NaCl)
- Administered via:
- IV bolus (over 3–5 minutes)
- IV infusion (over 15–30 minutes)
- Dose and frequency depend on:
- Patient’s age and weight
- Severity of infection
- Kidney function
⚠️ Patient Advice / Precautions:
- Strictly for hospital/injection use only – not oral
- Dose adjustment needed in renal impairment
- Use with caution in patients with history of seizures or beta-lactam allergy
- Inform doctor if:
- Pregnant or breastfeeding
- Having neurological disorders (e.g., epilepsy)
🔄 Common Side Effects:
- Nausea, vomiting, diarrhea
- Headache
- Rash or pain at injection site
- Rare: Seizures (in high doses or kidney dysfunction)
📦 Common Packaging:
- Glass vial with 1 g Meropenem (as trihydrate)
- Usually comes without diluent – to be mixed freshly before use
🧊 Storage:
- Store dry powder at room temperature (below 25°C)
- Once reconstituted:
- Use within 1 hour at room temperature
- Or store in refrigerator and use within 12–24 hours (based on institution policy)
- Do not freeze reconstituted solution