💉 Meglumine Diatrizoate Injection 76% w/v
📌 1. Prescription / Indication:
Meglumine Diatrizoate 76% w/v is a radiographic contrast agent used in:
- Angiography (cerebral, visceral, peripheral)
- Intravenous urography (IVU/IVP)
- Excretory urography
- Gastrointestinal imaging (oral or rectal) when barium is contraindicated
- CT imaging as contrast
- Hysterosalpingography (HSG)
📄 2. Description:
- Form: A sterile aqueous solution containing 76 g of meglumine diatrizoate per 100 mL
- Iodine content: Approximately 370 mg iodine/mL
- Nature: Ionic, high-osmolality iodinated contrast agent
- Appearance: Clear to pale yellow solution
- Osmolality: Very high (~2100–2400 mOsm/kg)
🌟 3. Advantages:
- Effective X-ray absorption due to high iodine concentration
- Economical and widely available
- Useful in emergencies and specific GI imaging where perforation is suspected
- Quick visualization in vascular and urinary tract imaging
🔬 4. Nature / Class:
- Pharmacologic class: Radiographic contrast agent
- Chemical class: Iodinated benzamide derivative (amidotrizoic acid salt with meglumine)
- Type: Ionic, high-osmolality contrast medium (HOCM)
- Excretion: Primarily renal, unchanged
📦 5. Common Packaging:
- Strength: 76% w/v (highest concentration available for this agent)
- Volumes: Typically 20 mL, 50 mL, 100 mL vials or ampoules
- Brand examples: Urografin®, Renografin®, Gastrografin® (when mixed)
🧊 6. Storage:
- Store at 20–25°C (68–77°F)
- Protect from light
- Do not freeze
- Use aseptically and discard unused portion after opening (single-use)
👩⚕️ 7. Patient Advice:
- Inform your doctor if you have:
- Allergies (especially to iodine or contrast media)
- Kidney disease or diabetes (especially on metformin)
- Heart conditions or asthma
- Drink plenty of fluids before and after the scan
- Possible side effects:
- Mild: Warm sensation, nausea, headache
- Serious (rare): Allergic reactions, anaphylaxis, kidney dysfunction
🎯 8. Purpose & Route of Administration:
| Route | Purpose |
|---|---|
| Intravenous (IV) | Urography, angiography, CT contrast studies |
| Oral/Rectal | GI tract studies when barium is unsafe |
| Intrauterine | Hysterosalpingography (HSG) |
| Intra-arterial | Vascular diagnostic imaging |
⚠️ Precautions:
- Not for intrathecal use (risk of neurotoxicity)
- Monitor renal function in elderly, diabetics, or dehydrated patients
- Avoid in thyroid disorders due to iodine load
- High osmolality may increase risk of:
- Hypotension
- Bradycardia
- Contrast-induced nephropathy (CIN)