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💊 Mefloquine Tablet 250 mg
📘 Description:
- Mefloquine 250 mg tablet is an antimalarial medication, usually presented as a film-coated oral tablet.
- Each tablet contains mefloquine hydrochloride, equivalent to 250 mg of mefloquine base.
- It is primarily used for both the treatment and prophylaxis of malaria, especially Plasmodium falciparum.
- The tablets are usually white or off-white and may be scored for easy splitting.
- Marketed under brand names like Lariam®, Mefliam, or Mephaquin.
🌿 Nature:
- Mefloquine is a quinoline methanol derivative, chemically related to quinine.
- It acts by inhibiting parasite DNA and heme polymerization, leading to toxic heme accumulation.
- It is effective against blood schizonts of malaria parasites but not against liver stages.
- Mefloquine has a long elimination half-life (~20 days), enabling weekly dosing for prophylaxis.
- It crosses the blood-brain barrier, which is linked to some of its neuropsychiatric effects.
✅ Advantages:
- Effective against chloroquine-resistant P. falciparum malaria.
- Its long half-life allows weekly dosing, improving adherence in malaria prevention.
- Well absorbed orally with good bioavailability.
- Useful for travelers to endemic areas due to its prophylactic utility.
- Can be co-administered with artesunate in combination therapy.
🩺 Uses:
- Prophylaxis of malaria, especially in regions with drug-resistant P. falciparum.
- Treatment of uncomplicated malaria due to P. falciparum (in combination regimens).
- Part of artemisinin-based combination therapy (ACT) in some national malaria programs.
- Occasionally used in mass treatment campaigns in high-endemic areas.
- May be considered for rescue treatment in case of treatment failure from other drugs.
❄️ Storage:
- Store below 25°C (77°F) in a cool, dry place.
- Protect from light, heat, and moisture.
- Keep in original blister pack or bottle until use.
- Ensure it is securely stored away from children.
- Do not use after expiry date mentioned on packaging.
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