💉 Magnesium Sulphate Injection 500 mg/mL
📌 1. Prescription / Indications:
Magnesium sulphate injection 500 mg/mL is commonly prescribed for:
- Severe preeclampsia and eclampsia (to prevent and treat seizures in pregnancy)
- Hypomagnesemia (magnesium deficiency)
- Torsades de pointes (a specific type of ventricular tachycardia)
- Acute asthma exacerbations (as a bronchodilator adjunct)
- Neuroprotection in preterm labor (for fetal benefit)
📄 2. Description:
- Generic Name: Magnesium Sulphate
- Concentration: 500 mg/mL
- Form: Aqueous injectable solution
- Appearance: Clear, colorless solution
- Route: Intravenous (IV) or Intramuscular (IM)
- Formulation Note: Equivalent to ~49.3 mg elemental magnesium per mL
🔬 3. Nature / Drug Class:
- Electrolyte supplement and anticonvulsant
- Acts as a CNS depressant, vasodilator, and smooth muscle relaxant
🌟 4. Advantages:
- Rapid seizure control in eclampsia
- Reduces risk of recurrent seizures in pregnancy
- Effective in correcting hypomagnesemia
- Cardioprotective in certain arrhythmias (like torsades)
- Acts as adjunctive bronchodilator in severe asthma
📦 5. Common Packaging:
| Volume | Packaging Type |
|---|
| 2 mL, 5 mL, 10 mL, 20 mL | Glass ampoules or vials |
- Each mL contains 500 mg of magnesium sulphate heptahydrate
🧊 6. Storage:
- Store at controlled room temperature (15°C to 25°C)
- Do not refrigerate or freeze
- Protect from light and contamination
- Check for precipitate or discoloration before use
👩⚕️ 7. Patient Advice:
- Administered only under medical supervision (IV/IM)
- May feel warmth, flushing, or dizziness during infusion
- Inform your provider if you have:
- Kidney disease
- Heart block
- Calcium imbalance
- If used in pregnancy, close monitoring of reflexes, respiratory rate, and urine output is essential
🎯 8. Purpose / Clinical Use:
| Clinical Use | Purpose |
|---|
| Eclampsia/preeclampsia | Prevent and treat seizures |
| Hypomagnesemia | Correct magnesium deficiency |
| Torsades de pointes | Stabilize cardiac rhythm |
| Severe asthma | Adjunctive bronchodilator (via IV infusion) |
| Neuroprotection | Reduce risk of cerebral palsy in preterm labor |
⚠️ 9. Warnings / Precautions:
- Risk of magnesium toxicity — monitor serum levels
- Signs of toxicity:
- Loss of deep tendon reflexes
- Respiratory depression
- Hypotension
- Cardiac arrhythmia
- Calcium gluconate is the antidote for magnesium toxicity
- Use cautiously in renal impairment (magnesium is renally excreted)
