💉 Lorazepam Injection 2 mg/mL
📌 1. Prescription / Indications:
Lorazepam Injection 2 mg/mL is commonly prescribed for:
- Status epilepticus and acute seizures
- Severe anxiety and agitation in emergency settings
- Preoperative sedation
- Procedural sedation
- Adjunct for acute alcohol withdrawal symptoms
📄 2. Description:
- Active Ingredient: Lorazepam
- Concentration: 2 mg/mL
- Dosage Form: Injection (ampoule or vial)
- Route of Administration: Intravenous (IV) or Intramuscular (IM)
🔬 3. Nature / Drug Class:
- Pharmacological Class: Benzodiazepine
- Mechanism of Action: Potentiates GABA-A receptor activity → CNS depression → anxiolytic, sedative, anticonvulsant, and muscle-relaxing effects
🌟 4. Advantages:
- Fast-acting; preferred agent in status epilepticus
- Effective sedative for procedures or pre-anesthetic use
- Longer duration of action compared to diazepam in seizure control
- Can be given IV or IM depending on situation
📦 5. Common Packaging:
| Strength | Form | Pack Type |
|---|
| 2 mg/mL | 1 mL/2 mL vial or ampoule | Glass ampoules or vials (single-dose) |
🧊 6. Storage:
- Store at 2°C to 8°C (Refrigerated)
- Protect from light
- Do not freeze
- Discard if solution becomes cloudy or discolored
👩⚕️ 7. Patient Advice:
- Administered by healthcare professional only
- May cause drowsiness, low blood pressure, slowed breathing
- Inform healthcare provider if there’s history of lung disease, sleep apnea, liver/kidney disease, or substance abuse
- Avoid driving or operating machinery after administration
- Let your doctor know if you’re pregnant or breastfeeding
🎯 8. Purpose / Clinical Use:
| Clinical Use | Role of Lorazepam Injection |
|---|
| Status epilepticus | First-line or adjunct anticonvulsant |
| Severe agitation | Rapid sedation in psychiatric cases |
| Premedication | Sedative before surgery/procedure |
| Acute alcohol withdrawal | To manage seizures, agitation, anxiety |
⚠️ 9. Warnings / Precautions:
- IV administration may cause respiratory depression, especially when combined with opioids or alcohol
- Monitor vitals closely during and after administration
- May cause injection site reactions
- Use cautiously in elderly or those with compromised respiratory function
- Slow IV push over 2 minutes recommended for safety
