đź’Š Levetiracetam Modified Release (MR) Tablet 750 mg
đź“Ś 1. Prescription / Indication:
Levetiracetam MR 750 mg is prescribed for the treatment of epilepsy, specifically:
- Partial-onset seizures in adults and adolescents ≥16 years
- Used when once-daily dosing is preferred
- Monotherapy or adjunctive therapy
đź“„ 2. Description:
- Form: Modified Release (MR) / Extended Release (XR) tablet
- Strength: 750 mg
- Appearance: Varies by manufacturer—often oblong, film-coated
- Route: Oral
- Pharmacokinetics:
- Designed for slow and steady drug release over 24 hours
- Maintains stable plasma levels
- Once-daily dosing improves adherence
🔬 3. Nature / Class:
- Therapeutic class: Antiepileptic (AED)
- Mechanism of Action:
Binds to SV2A (synaptic vesicle protein 2A) in the brain to reduce abnormal neuronal firing and prevent seizures.
🌟 4. Advantages:
- Once-daily dosing improves convenience and compliance
- Reduced fluctuations in plasma levels
- Fewer side effects like sedation compared to immediate-release (IR)
- Useful for long-term maintenance therapy
- Can be used in combination with other AEDs
📦 5. Common Packaging:
| Form | Details |
|---|---|
| Blister packs | 10 tablets per strip |
| Boxes | Usually 3–10 strips per box |
| HDPE bottles | Available in some settings |
🧊 6. Storage:
- Store at 15°C to 30°C (59–86°F)
- Keep away from heat and moisture
- Protect from light
- Store in original packaging until use
- Keep out of reach of children
👩‍⚕️ 7. Patient Advice:
- Swallow whole—do not crush, chew, or break MR tablets
- Take at the same time daily (preferably evening)
- Do not skip or stop abruptly—can trigger seizures
- May cause drowsiness, dizziness, or mood changes
- Report unusual behavior, suicidal thoughts, or skin reactions
- Not usually recommended during pregnancy unless necessary
- Renal function should be monitored; dose adjustments may be required
🎯 8. Purpose / Uses:
| Seizure Type | Use |
|---|---|
| Partial-onset seizures | Long-term management |
| Generalized epilepsy* | Off-label in some cases |
* Based on physician’s discretion and clinical context
⚠️ 9. Precautions / Warnings:
- Renal impairment: Dose modification required
- Hepatic impairment: Generally safe, minimal liver metabolism
- Avoid alcohol or sedatives during therapy
- Monitor mood/behavioral changes in patients
- Not interchangeable with immediate-release without dose adjustment