💉 Levetiracetam Injection 100 mg/mL
📌 1. Prescription / Indication:
Levetiracetam Injection is prescribed for:
- Treatment of seizures when oral administration is not feasible, such as:
- In emergency settings (e.g. status epilepticus)
- Pre- or post-surgery
- Unconscious patients
- Used as monotherapy or adjunct therapy for:
- Partial-onset seizures
- Myoclonic seizures
- Generalized tonic-clonic seizures
📄 2. Description:
- Form: Sterile injectable solution
- Strength: 100 mg of levetiracetam per 1 mL
- Available vial sizes: 5 mL or 10 mL (commonly 500 mg/5 mL or 1000 mg/10 mL)
- Route: Intravenous (IV) use only
🔬 3. Nature / Class:
- Pharmacologic class: Antiepileptic drug (AED)
- Mechanism of Action:
Binds to SV2A protein on synaptic vesicles → modulates neurotransmitter release → stabilizes abnormal brain activity.
🌟 4. Advantages:
- Rapid action — ideal for acute seizure control
- Useful for patients who cannot swallow
- Can be switched to oral form when stable
- Does not require liver enzyme monitoring like some older AEDs
- No significant drug interactions with common medications
📦 5. Common Packaging:
| Volume | Total Drug Content | Type |
|---|---|---|
| 5 mL vial | 500 mg | Glass vial |
| 10 mL vial | 1000 mg | Glass vial |
Each mL contains:
- Levetiracetam 100 mg
- Sodium acetate buffer and water for injection
- pH adjusted (about 5.5–6.5)
🧊 6. Storage:
- Store at 15°C to 30°C (59°F to 86°F)
- Protect from light
- Do not freeze
- Use immediately after opening
- Once diluted for IV infusion, use within 24 hours if refrigerated
👩⚕️ 7. Patient Advice
- Administered under medical supervision
- Dosing based on weight and renal function
- May cause drowsiness, dizziness, or fatigue
- Possible behavioral changes — report agitation or mood shifts
- May transition to oral form once stable
- Should not be self-administered
🎯 8. Purpose / Uses:
| Condition | Use |
|---|---|
| Acute partial seizures | IV monotherapy or adjunct |
| Generalized seizures (status) | Emergency control |
| Transition from oral therapy | Temporary substitution |
| Surgery-related seizure risk | Preventive administration |
⚠️ 9. Precautions / Warnings:
- Adjust dose in renal impairment
- Monitor for signs of psychosis, aggression, depression
- Caution in pregnancy — use only if clearly needed
- Not to be mixed with other IV medications unless confirmed compatible
- Observe for allergic reactions (rare)