Here is the detailed information for Leuprolide Acetate Powder for Injection 22.5 mg:
💉 Leuprolide Acetate – Powder for Injection 22.5 mg
🔹 Description:
Leuprolide acetate is a synthetic gonadotropin-releasing hormone (GnRH) agonist. It works by initially stimulating, then suppressing the pituitary secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby reducing sex hormone levels (testosterone or estrogen).
🔬 Nature / Drug Class:
- Nature: Synthetic long-acting hormone analog
- Drug Class: GnRH agonist / LHRH analog
🎯 Purpose / Indications:
- Advanced prostate cancer (palliative treatment)
- Endometriosis
- Uterine fibroids
- Central precocious puberty (CPP)
- Hormone-dependent breast cancer (off-label use)
- Fertility suppression in certain reproductive treatments
✅ Advantages:
- Three-month depot formulation – administered once every 12 weeks
- Reduces frequency of injections, enhancing patient compliance
- Effectively suppresses hormone production over extended periods
- Reduces disease symptoms and progression in hormone-sensitive conditions
📦 Common Packaging:
- Single-dose vial of 22.5 mg lyophilized powder
- Accompanied by sterile diluent for reconstitution
- Administered as intramuscular (IM) injection
⚠️ Patient Advice / Precautions:
- May cause initial symptom flare before hormone suppression begins
- Long-term use may lead to bone mineral loss (osteoporosis risk)
- Regular monitoring of hormone levels, bone density, and glucose (in diabetic patients) recommended
- Not for use in pregnancy or lactation
- Injection should be prepared and given under medical supervision