Here is a detailed overview of Irinotecan Hydrochloride Trihydrate Injection 20 mg/mL with icons:
💉 Irinotecan Hydrochloride Trihydrate Injection 20 mg/mL
🧪 Nature / Drug Class
🔹 Antineoplastic (Chemotherapy) Agent
🔹 Topoisomerase I Inhibitor
🔹 Semi-synthetic derivative of camptothecin
🩺 Purpose / Indications
✅ Used in the treatment of various solid tumors, especially:
- 🦠 Metastatic Colorectal Cancer
- 🫁 Non-small Cell Lung Cancer (NSCLC)
- 🧫 Off-label use in pancreatic, cervical, gastric, and ovarian cancers
⚙️ Advantages
✔️ Often combined with 5-FU + leucovorin (FOLFIRI regimen)
✔️ Useful in both first-line and second-line treatment
✔️ Available in ready-to-use solution – no powder reconstitution required
✔️ Proven efficacy in advanced/metastatic cases
📦 Common Packaging
📦 Vial: 20 mg/mL strength
💉 Available in:
- 2 mL (40 mg)
- 5 mL (100 mg)
- 15 mL (300 mg)
🧪 Clear, colorless to pale yellow solution
⚠️ Patient Advice / Precautions
🩸 Administered via IV infusion (over 90 minutes)
💊 Premedication may be needed for nausea/vomiting
🚽 Risk of diarrhea:
- Early-onset (cholinergic symptoms) – treat with atropine
- Late-onset (secretory) – treat with loperamide
🧪 Monitor: - CBC (neutropenia risk)
- Liver function
- Hydration status
🚫 Avoid use in pregnancy and lactation
❗ Caution in patients with UGT1A1*28 mutation – higher risk of toxicity
🧊 Storage
🌡️ Store at 15–30°C (room temperature)
🚫 Protect from light and freezing
🧴 Use immediately or as per manufacturer’s stability after opening
🧒 Keep out of reach of children