💊 Ibuprofen Tablet 400 mg
📘 Description:
Ibuprofen 400 mg is a non-steroidal anti-inflammatory drug (NSAID) used for relief of moderate pain, inflammation, and fever. It is commonly used in musculoskeletal disorders, dental pain, dysmenorrhea, and fever. This strength is typically available by prescription in many countries.
🔬 Formulation:
- Active Ingredient: Ibuprofen
- Strength: 400 mg per tablet
- Route: Oral
- Form: Tablet, film-coated or soft gel
🧪 Nature / Mechanism of Action:
- Drug Class: NSAID (Propionic acid derivative)
- Mechanism:
- Non-selective inhibition of COX-1 and COX-2 enzymes
- ↓ Prostaglandin synthesis → ↓ pain, inflammation, fever
🩺 Uses / Indications:
| Condition | Use |
|---|---|
| Post-operative pain | Short-term relief |
| Menstrual pain (dysmenorrhea) | Anti-inflammatory analgesia |
| Musculoskeletal pain | Sprains, strains, arthritis |
| Dental pain | Relief after extraction, infection |
| Fever | Antipyretic action |
| Headache / migraine | Effective in tension-type pain |
| Gout (acute attack) | Reduces inflammation |
✅ Advantages:
- Stronger dose than 200 mg → longer duration & improved effect
- Fast onset of action (30–45 minutes)
- Multiple indications (analgesic, antipyretic, anti-inflammatory)
- May be combined with paracetamol or other agents under medical advice
- Often used in orthopedic and dental settings
⚠️ Precautions:
Use with caution or avoid in:
- History of gastric ulcers or bleeding
- Cardiovascular disease (hypertension, heart failure)
- Renal impairment or dehydration
- Hepatic dysfunction
- Asthma sensitive to NSAIDs
- Pregnancy (3rd trimester) – may cause premature closure of ductus arteriosus
- Breastfeeding: Small amounts may pass into milk — use with medical advice
📦 Storage:
- Store at 15–25°C
- Keep away from heat and moisture
- Store in original blister to protect from light