Here’s the detailed profile for Ethambutol Tablet 400 mg 👇
💊 Ethambutol Tablet 400 mg
📘 Description:
- Ethambutol is a first-line antituberculosis drug.
- Mechanism: Inhibits arabinoglycan (cell wall) synthesis in Mycobacterium tuberculosis, leading to disruption of bacterial growth.
- Always used in combination with other TB medicines.
📄 Prescription / Indications:
- Pulmonary TB and extrapulmonary TB.
- Used in both intensive and continuation phases of TB treatment.
- Helps prevent drug resistance when combined with isoniazid, rifampicin, and pyrazinamide.
🌿 Nature / Drug Class:
- Antimycobacterial agent
- Cell wall synthesis inhibitor
✅ Advantages:
- Standard first-line TB therapy drug.
- Useful for both new and retreatment TB cases.
- Helps protect other TB drugs from resistance development.
⚠️ Precautions:
Contraindications:
- Known hypersensitivity to Ethambutol.
Caution in:
- Eye disorders (optic neuritis, vision problems) – may worsen.
- Renal impairment – dose adjustment required.
- Children <5 years (difficulty monitoring vision changes).
Adverse Effects:
- Optic neuritis (dose and duration related) → decreased visual acuity, red-green color blindness.
- GI upset, rash, headache.
- Rare: Peripheral neuropathy.
💊 Dosage (Adults):
- 15–25 mg/kg body weight per day, orally in single daily dose.
- For a 60 kg patient → 900–1500 mg/day (so 400 mg tablets are used in multiples to reach target dose).
- Always given as part of multidrug TB regimen.
📦 Common Packaging:
- Blister or strip packs of 400 mg tablets (common standard strength).
- Also found in Fixed-Dose Combinations (FDCs) with isoniazid, rifampicin, and pyrazinamide.
❄️ Storage:
- Store below 25°C, dry place.
- Protect from light and moisture.