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📌 Entecavir Tablet 0.5 mg
💊 Description:
- Entecavir 0.5 mg is an oral antiviral drug used to treat chronic hepatitis B infection.
- It belongs to the nucleoside analogue class that targets viral replication enzymes.
- The tablet is film-coated and taken once daily, typically on an empty stomach.
- It acts specifically on HBV DNA polymerase, halting the virus’s ability to multiply.
- This dose is commonly prescribed to treatment-naive adults with stable liver function.
🌿 Nature:
- Entecavir is a nucleoside analogue reverse transcriptase inhibitor (NRTI).
- It mimics a natural DNA building block (guanosine) to disrupt viral DNA synthesis.
- It has a high selectivity for HBV over human polymerases, minimizing toxicity.
- The drug is well-absorbed orally and reaches peak plasma levels within 1–2 hours.
- Comes in a tablet form that is stable under normal storage conditions.
✅ Advantages:
- Offers potent suppression of HBV DNA levels in both HBeAg-positive and negative patients.
- Has a high genetic barrier to resistance, especially in treatment-naive individuals.
- Helps improve liver histology and reduce inflammation and fibrosis over time.
- Shows a low incidence of adverse effects, making it suitable for long-term use.
- Can significantly delay or prevent progression to cirrhosis and liver cancer.
🩺 Uses:
- Used for the treatment of chronic hepatitis B in adults and children over 2 years.
- Indicated in patients with active viral replication and elevated liver enzymes.
- Suitable for those with compensated liver disease and minimal fibrosis.
- May be used as HBV prophylaxis in patients undergoing immunosuppressive therapy.
- Also considered in HBV/HIV coinfected individuals (under careful monitoring).
❄️ Storage:
- Store below 30°C (86°F) in a cool, dry environment.
- Keep away from direct sunlight and moisture to prevent degradation.
- Always retain in original packaging or container with the lid tightly closed.
- Do not use tablets that are chipped, discolored, or past expiry.
- Keep out of reach of children and pets for safety.
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