💉 Enoxaparin Injection 60 mg/0.6 mL
🔹 1. Prescription / Indication:
Enoxaparin 60 mg/0.6 mL is typically prescribed for treatment (not just prevention) of blood clots:
- Treatment of Deep Vein Thrombosis (DVT) with or without Pulmonary Embolism (PE)
- Treatment of acute coronary syndromes, including:
- Unstable angina
- Non–ST-elevation myocardial infarction (NSTEMI)
- Prevention of clot formation in patients undergoing:
- Hemodialysis
- High-risk surgeries
- Can also be used in COVID-19-associated coagulopathy (per hospital protocol)
✅ This therapeutic dose is usually given twice daily or once daily, depending on the patient’s weight and renal function.
🔹 2. Description:
- Form: Pre-filled syringe
- Strength: 60 mg enoxaparin in 0.6 mL solution
- Appearance: Clear, colorless to pale yellow liquid
- Route: Subcutaneous injection (SC)
🔹 3. Advantages:
- Stable, predictable anticoagulant effect
- No need for regular blood test monitoring (e.g., INR)
- Less risk of Heparin-Induced Thrombocytopenia (HIT)
- Longer duration of action than unfractionated heparin
- Can be self-administered by patients at home
- Available with safety lock syringes
🔹 4. Nature / Pharmacological Class:
- Class: Low Molecular Weight Heparin (LMWH)
- Mechanism:
- Inhibits Factor Xa (primarily) and Factor IIa (thrombin)
- Prevents fibrin clot formation
🔹 5. Common Packaging:
- Pre-filled syringes:
- 60 mg/0.6 mL
- Usually packed as:
- Single-use syringes
- Boxes of 2, 10, or 20
- May come with or without automatic needle safety system
🔹 6. Storage:
- Store at 15–25°C (59–77°F)
- Do not freeze
- Keep in original packaging to protect from light
- Keep away from children
🔹 7. Patient Advice / Counseling Points:
- Inject subcutaneously, usually into the abdomen (at least 5 cm from the navel)
- Rotate injection sites
- Do not massage or rub the site after injection
- Dispose of used syringes in a sharps container
- Do not remove air bubble from syringe (it helps reduce bruising)
- Report signs of bleeding or low platelets:
- Unusual bruising
- Nosebleeds, gum bleeding
- Blood in urine or stool
- Dizziness or headache
- Avoid NSAIDs, aspirin, or other anticoagulants unless directed
- Inform your doctor before:
- Surgery
- Spinal/epidural anesthesia
- Special caution in kidney disease, elderly, and underweight/overweight patients
🔹 8. Purpose / Use:
- Treatment of active DVT/PE
- Prevention of clot complications in heart disease
- Bridge therapy when switching from oral anticoagulants
- Used in high-risk medical conditions including:
- COVID-19 with coagulopathy
- Cancer
- Pregnancy (under specialist supervision)