💊 Domperidone Tablet 10 mg – As Licensed
📄 Description:
Domperidone 10 mg Tablet is a prokinetic and antiemetic agent. It enhances gastrointestinal motility and blocks dopamine receptors in the chemoreceptor trigger zone (CTZ), thereby reducing nausea and vomiting.
🧾 Prescription / Indications:
Prescribed for:
- Nausea and vomiting (due to various causes including medications, infections, or GI disorders)
- Gastroesophageal reflux disease (GERD)
- Functional dyspepsia
- Delayed gastric emptying
- Sometimes used to enhance lactation (off-label)
Usual adult dose:
- 10 mg 3 times daily, 15–30 minutes before meals
- Maximum: 30 mg/day
- Duration should generally not exceed 1 week without re-evaluation
🔬 Nature:
- Class: Dopamine (D2) receptor antagonist
- Type: Antiemetic and gastroprokinetic agent
- Formulation: Oral tablet, 10 mg
🌟 Advantages:
- Effective in relieving nausea, vomiting, bloating
- Helps in accelerating gastric emptying
- Does not cross the blood-brain barrier significantly, so fewer CNS side effects compared to metoclopramide
- Can be used in patients intolerant to metoclopramide
📦 Packaging:
- Blister packs of 10 or 15 tablets per strip
- Common brand/trade names may vary across manufacturers
🧊 Storage:
- Store in a cool, dry place below 25°C
- Protect from moisture and direct sunlight
- Keep out of reach of children
⚠️ Precautions:
- Contraindicated in:
- Known prolonged QT interval
- Severe hepatic impairment
- Concomitant use of QT-prolonging drugs (e.g., erythromycin, ketoconazole)
- Use with caution in elderly patients or those with cardiac conditions
- Monitor for signs of cardiac arrhythmia (especially with high doses)
Side Effects:
- Dry mouth
- Abdominal cramps
- Rare: QT prolongation, dizziness, palpitations
👩⚕️ Patient Advice:
- Take the tablet 15 to 30 minutes before meals
- Do not exceed the prescribed dose
- Inform your doctor if you experience:
- Irregular heartbeat
- Severe abdominal pain
- Breast tenderness or menstrual changes
- Avoid taking it with antacids or acid blockers at the same time – they can reduce its effectiveness
- Report use of other medications, especially antibiotics or antifungals