Here is the detailed information for Dolutegravir 50 mg Tablet:
💊 Dolutegravir Tablet 50 mg
🧪 Composition:
- Dolutegravir sodium equivalent to Dolutegravir 50 mg
🌐 Therapeutic Class:
- Antiretroviral
- Integrase Strand Transfer Inhibitor (INSTI)
✅ Indications / Uses:
- Treatment of HIV-1 infection in adults and children (≥6 years and ≥25 kg)
- Used:
- Alone or
- In fixed-dose combinations with other antiretrovirals like Lamivudine or Tenofovir + Lamivudine
⚖️ Dosage:
- Treatment-naïve adults and adolescents:
- 50 mg once daily, with or without food
- With certain enzyme-inducing drugs (e.g., rifampicin):
- 50 mg twice daily
⚠️ Precautions:
- Hypersensitivity reactions (rare but serious)
- Monitor for immune reconstitution inflammatory syndrome (IRIS)
- Can cause elevated liver enzymes, especially in HBV/HCV co-infection
- Weight gain may occur
- Use caution with antacids, calcium, iron (may reduce absorption – separate by several hours)
🚫 Contraindications:
- Hypersensitivity to Dolutegravir
- Concomitant use with dofetilide (risk of life-threatening arrhythmias)
💥 Common Side Effects:
- Insomnia
- Headache
- Diarrhea
- Dizziness
- Weight gain
- Increased liver enzymes
👩⚕️ Use in Special Populations:
- Pregnancy: Generally safe and recommended in WHO guidelines
- Breastfeeding: Avoid if possible due to limited data
- Children: Approved for use in children ≥6 years and ≥25 kg
📦 Storage:
- Store below 30°C, in a dry place
- Protect from light and moisture