Here is the complete information for Delamanid Tablet 50 mg:
💊 Delamanid Tablet 50 mg
🧪 Generic Name:
Delamanid
📦 Strength & Form:
- Tablet: 50 mg
- Oral administration
🩺 Indications / Uses:
Used only for:
- Multidrug-Resistant Tuberculosis (MDR-TB)
- In combination with other second-line anti-TB drugs
Not for monotherapy. Reserved for programmatic use under TB control programs.
⚖️ Dosage (Adults):
As per WHO and National TB Guidelines:
- Weeks 1–8:
100 mg twice daily (i.e. 2 tablets per day, 12-hour gap) - Weeks 9–24:
100 mg once daily
Total Duration: Up to 6 months, often alongside drugs like Bedaquiline
⚠️ Precautions:
- QT prolongation: Requires regular ECG monitoring
- Do not co-administer with other QT-prolonging drugs unless strictly needed
- Hepatotoxicity risk → monitor liver function
- Take with food for better absorption
- Must be used only under specialist supervision
🚫 Contraindications:
- Known allergy to Delamanid
- History of cardiac arrhythmia or QT prolongation
- Concurrent use of strong CYP3A4 inducers (e.g., rifampicin)
💥 Common Side Effects:
- Nausea, vomiting
- Dizziness, headache
- Low potassium or magnesium
- QT prolongation
- Insomnia or anxiety
📌 Special Notes:
- Used under NTEP/DOTS Plus for MDR/XDR TB
- Often part of longer regimens with Linezolid, Clofazimine, etc.
- Not recommended in children <18 years, pregnancy, or lactation without expert consultation