Here is a detailed overview of the combination:
Darunavir (600 mg) + Ritonavir (100 mg) Tablet with icons.
💊 Darunavir 600 mg + Ritonavir 100 mg Tablet
🧪 Nature / Drug Class
🔹 Darunavir – Protease Inhibitor (PI)
🔹 Ritonavir – Pharmacokinetic booster (also a PI)
🧬 Together, they inhibit HIV protease enzyme and enhance drug levels
🩺 Purpose / Indications
✅ Used for HIV-1 infection, typically in:
- 👤 Treatment-experienced patients with resistant virus
- 🧫 Second-line or salvage therapy
- 🔁 Boosted PI regimen in combination with other antiretrovirals
⚙️ Advantages
✔️ Darunavir has high potency and works against resistant HIV strains
✔️ Ritonavir boosts darunavir levels by slowing its metabolism
✔️ Effective once or twice daily depending on regimen
✔️ Can be co-administered with NRTIs or integrase inhibitors
📦 Common Packaging
📦 Tablet contains:
- 💊 Darunavir: 600 mg
- 💊 Ritonavir: 100 mg
🧴 Usually packed in bottles or blisters of 30 or 60 tablets
⚠️ Patient Advice / Precautions
🍽️ Must be taken with food – enhances absorption
🕐 Usually taken twice daily unless part of simplified regimen
🧪 Monitor:
- Liver function (risk of hepatitis)
- Lipid profile and glucose (can raise levels)
💊 Many drug interactions – avoid certain sedatives, statins, anticonvulsants
🚫 Not recommended in severe liver impairment
🧊 Storage
🌡️ Store at room temperature
🚫 Protect from moisture and light
🧒 Keep away from children