Here’s the detailed profile for Dapsone Tablet 100 mg 👇
💊 Dapsone Tablet 100 mg
📘 Description:
- Dapsone is a synthetic sulfone antibiotic.
- It is bacteriostatic against Mycobacterium leprae and some other pathogens.
- Has anti-inflammatory activity, which also makes it useful in dermatological diseases.
- Core drug in WHO-recommended multidrug therapy (MDT) for leprosy.
📄 Prescription / Indications:
- Leprosy (Hansen’s disease) – as part of MDT (with rifampicin ± clofazimine)
- Dermatitis herpetiformis (chronic blistering autoimmune skin condition)
- Pneumocystis jirovecii pneumonia (PCP) – prophylaxis or treatment (if co-trimoxazole not tolerated)
- Toxoplasmosis prophylaxis (alternative role)
🌿 Nature / Drug Class:
- Sulfone class drug
- Antimycobacterial and anti-inflammatory
✅ Advantages:
- Key drug for leprosy MDT – prevents emergence of resistance
- Once-daily dosing improves compliance
- Effective alternative in PCP prophylaxis when sulfa drugs are not tolerated
⚠️ Precautions:
Contraindications:
- Known hypersensitivity to dapsone or sulfone group drugs
- Severe anemia
Use with caution in:
- G6PD deficiency – risk of hemolysis & methemoglobinemia
- Renal or hepatic impairment
- HIV patients on long-term prophylaxis – risk of hematological toxicity
Adverse effects:
- Common: nausea, vomiting, headache, rash, pruritus
- Hematological: hemolysis (especially in G6PD deficiency), methemoglobinemia, agranulocytosis, aplastic anemia
- Dermatological: photosensitivity, exfoliative dermatitis
- Serious: Dapsone Hypersensitivity Syndrome (fever, rash, hepatitis, lymphadenopathy, sometimes fatal)
💊 Dosage (Adults):
- Leprosy (MDT): 100 mg once daily (self-administered, long-term therapy)
- Dermatitis herpetiformis: 50–100 mg daily (adjusted per response)
- PCP prophylaxis (alternative): 100 mg once daily
👉 100 mg tablet is the standard adult dose in MDT for leprosy.
📦 Common Packaging:
- Tablets: 100 mg (also available in 50 mg for pediatrics or dose adjustments)
- Supplied in blister strips or bottles
- Included in WHO MDT blister packs for adult leprosy patients
❄️ Storage Conditions:
- Store at room temperature (<25°C)
- Keep in a dry place, away from light & moisture
- Keep out of reach of children