D- Penicillamine Capsule 150 mg (p)

💊 D-Penicillamine 150 mg Capsule (Prescription)

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🔹 Generic Name:

D-Penicillamine

🔹 Strength & Form:

• 150 mg capsule
• Prescription-only (marked as (p))

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📌 Description:

D-Penicillamine is a chelating agent and disease-modifying antirheumatic drug (DMARD). It binds to heavy metals and cystine, aiding in their excretion, and modifies the immune response in autoimmune diseases.

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✅ Indications / Uses:

Condition	Purpose
Wilson’s Disease	Removes excess copper from the body
Rheumatoid Arthritis	Second-line treatment (when others fail)
Cystinuria	Prevents cystine stone formation
Heavy Metal Poisoning	Chelates lead, mercury, and other metals
Scleroderma (off-label)	May reduce skin thickening (rare use)

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💊 Dosage:

Condition	Adult Starting Dose	Notes
Wilson’s Disease	250 mg once daily, then increase to 750–1,500 mg/day in divided doses	Take on empty stomach
RA	125–250 mg/day → gradually increase to 500–750 mg/day	Monitor closely
Cystinuria	1–2 grams/day in divided doses	Maintain hydration & alkaline urine

✅ Advantages:

• Effective copper chelation in Wilson’s disease
• Reduces progression of rheumatoid arthritis (when others fail)
• Prevents recurrent kidney stones in cystinuria

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⚠️ Precautions & Warnings:

Risk Factor	Precaution
Pregnancy Category D	Teratogenic — avoid unless benefit outweighs risk
Renal disease	Use with caution — nephrotoxicity possible
Bone marrow suppression	Regular blood counts required
Hypersensitivity reactions	Rash, fever, and lymphadenopathy possible

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🧪 Pharmacological Nature:

Property	Detail
Class	Chelating agent / DMARD
Bioavailability	Moderate
Onset of action	Weeks (RA), days (chelation)
Excretion	Urine (as chelate complexes)

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🧴 Storage:

• Store at room temperature (20–25°C)
• Protect from moisture and heat
• Keep in original container