Here is the detailed information for Clozapine Tablet 100 mg, with no brand names included:
💊 Clozapine Tablet 100 mg
✅ DESCRIPTION
Clozapine 100 mg is a prescription atypical antipsychotic used primarily for treatment-resistant schizophrenia and for reducing suicide risk in people with schizophrenia or schizoaffective disorder. It is especially effective in patients who have not responded to other antipsychotics.
🧪 FORMULATION
- Active Ingredient: Clozapine 100 mg
- Dosage Form: Oral tablet
- Route: Oral
- Common Excipients: Cellulose, starch, lactose, magnesium stearate (may vary)
- Color/Shape: Often yellow or white, scored tablet (appearance varies by manufacturer)
- Packaging: Blister strips or HDPE bottles
🌿 NATURE
- Drug Class: Atypical antipsychotic (Second-generation)
- Mechanism of Action:
- Blocks multiple neurotransmitter receptors: dopamine D2, serotonin 5-HT2A, muscarinic, histamine H1, and alpha-adrenergic
- Reduces psychotic symptoms and improves thought clarity with less motor side effects compared to older antipsychotics
💊 USES
- Schizophrenia (especially in treatment-resistant cases)
- Prevention of suicidal behavior in schizophrenia or schizoaffective disorder
- Off-label use: Psychosis in Parkinson’s disease (very low doses), bipolar disorder with psychosis
🌟 ADVANTAGES
- Superior efficacy in treatment-resistant cases
- Reduced extrapyramidal symptoms compared to first-generation antipsychotics
- Anti-suicidal effect
- Improves both positive and negative symptoms
- Lower risk of tardive dyskinesia
⚠️ PRECAUTIONS
🔬 Monitoring Required:
- White blood cell (WBC) and absolute neutrophil count (ANC) — mandatory regular monitoring
- ECG (for myocarditis risk), liver and kidney function tests, and weight/lipid/glucose profile
🚨 Serious Risks (Black Box Warnings):
- Agranulocytosis (neutropenia) — life-threatening, hence requires blood monitoring
- Seizures
- Myocarditis and cardiomyopathy
- Severe constipation or GI hypomotility
- Orthostatic hypotension and bradycardia
❗ Common Side Effects:
- Drowsiness or sedation
- Hypersalivation
- Weight gain
- Dizziness, headache
- Constipation
- Tachycardia
- Blurred vision
🚫 Contraindications:
- History of Clozapine-induced agranulocytosis
- Uncontrolled epilepsy
- Severe cardiovascular, renal, or hepatic impairment
- Known hypersensitivity to Clozapine
- Paralytic ileus
📋 DOSING INFORMATION
| Phase | Dosage Guidelines |
|---|---|
| Initial dose | 12.5–25 mg/day |
| Titration | Increase by 25–50 mg/day gradually |
| Maintenance | 300–450 mg/day (in divided doses) |
| Maximum Dose | Up to 900 mg/day (under specialist care) |
- 100 mg tablets are typically used during maintenance or moderate to high dose regimens.
🧊 STORAGE
- Store at 20°C to 25°C
- Protect from light, heat, and moisture
- Keep in original packaging until use
- Keep out of reach of children