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💉 Cloxacillin Powder for Injection 250 mg
📘 Description:
Cloxacillin 250 mg Injection is a penicillinase-resistant β-lactam antibiotic, supplied as a sterile powder for reconstitution and intravenous (IV) or intramuscular (IM) injection. It is used primarily to treat staphylococcal infections, especially those resistant to regular penicillin.
💊 Prescription / Indications:
Indicated for the treatment of moderate to severe infections, including:
- Skin and soft tissue infections
- Bone and joint infections (e.g., osteomyelitis)
- Respiratory tract infections
- Septicemia and bacteremia
- Endocarditis (as part of combination therapy)
- Surgical site infections
- Empiric therapy in suspected MSSA (Methicillin-Sensitive Staphylococcus aureus) infections
🩺 Uses:
- Active against β-lactamase-producing staphylococci
- Administered in hospital or supervised clinical settings
- Can be used in neonates, children, and adults depending on dose adjustments
- Suitable for serious infections requiring parenteral therapy
🌿 Nature:
- Drug Class: Penicillinase-resistant penicillin (β-lactam antibiotic)
- Form: Sterile powder for injection
- Route: IM / IV (after reconstitution)
- Mechanism of Action: Inhibits bacterial cell wall synthesis → Bactericidal
- Type: Prescription-only (Rx)
✅ Advantages:
- Rapid bactericidal action
- Stable against staphylococcal β-lactamase
- Lower risk of resistance compared to regular penicillin
- Well-tolerated in most patient groups
- Preferred in inpatient treatment of MSSA infections
⚠️ Precautions:
- Contraindicated in individuals allergic to penicillins or cephalosporins
- Adjust dose in patients with renal or hepatic impairment
- Monitor for side effects:
- Local injection site reactions (pain, swelling)
- Hypersensitivity reactions: rash, fever, anaphylaxis
- Rare: neutropenia, eosinophilia, elevated liver enzymes
- Use cautiously in neonates and preterm infants (due to immature renal function)
📦 Common Packaging:
- Glass vial containing sterile powder equivalent to 250 mg of cloxacillin sodium
- Usually supplied in packs of 1 or 10 vials
- Labeled for IM/IV use only
❄️ Storage:
- Store below 25°C, protected from light and moisture
- Reconstituted solution should be used immediately or as per manufacturer’s instructions
- Do not freeze the solution
- Discard any unused portion properly