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💊 Cloxacillin Capsule 500 mg
📘 Description:
Cloxacillin 500 mg is a penicillinase-resistant penicillin used to treat bacterial infections caused by β-lactamase-producing staphylococci. It is an oral capsule formulation for systemic antibacterial therapy.
💊 Prescription / Indications:
Prescribed for infections caused by methicillin-sensitive Staphylococcus aureus (MSSA) and other susceptible organisms, including:
- Skin and soft tissue infections (boils, cellulitis, impetigo)
- Osteomyelitis (bone infections)
- Respiratory tract infections (bronchitis, pneumonia)
- Septicemia
- Post-surgical wound infections
- Infected burns
- Endocarditis (in combination therapy)
🩺 Uses:
- Treatment of staph infections especially resistant to regular penicillin
- First-line choice for penicillinase-producing bacteria
- Used in outpatient oral antibiotic therapy (OOAT)
- Suitable for step-down therapy from IV to oral route in hospital patients
🌿 Nature:
- Class: Beta-lactam antibiotic, penicillin group
- Form: Hard gelatin capsule
- Route: Oral
- Mechanism: Inhibits bacterial cell wall synthesis → bactericidal
- Penicillinase-resistant
✅ Advantages:
- Stable against penicillinase enzymes
- Convenient twice to four times daily oral dosing
- Effective against many Gram-positive cocci
- Can be used as a follow-up to IV antibiotics
- Relatively low toxicity profile
⚠️ Precautions:
- Allergic reactions: Contraindicated in patients allergic to penicillin or cephalosporins
- Take on an empty stomach (1 hour before or 2 hours after food)
- Adverse effects may include:
- Nausea, vomiting
- Diarrhea
- Skin rash or urticaria
- Rare: hepatic dysfunction, neutropenia
- Monitor liver and kidney function in long-term use
- Not effective against MRSA (Methicillin-resistant Staph. aureus)
📦 Common Packaging:
- Supplied in strips or blister packs, each capsule containing:
- Cloxacillin Sodium equivalent to 500 mg cloxacillin
- Typically packed 10 capsules per strip
❄️ Storage:
- Store at or below 25°C
- Keep in a dry place, away from direct light and moisture
- Do not freeze
- Keep out of reach of children
- Do not use beyond expiry date