Clomiphene citrate Tablet 50 mg

🔹 Clomiphene Citrate Tablet 50 mg – As Licensed


📄 Description:

Clomiphene citrate is a selective estrogen receptor modulator (SERM) used primarily to treat female infertility due to anovulation or oligo-ovulation (especially in conditions like PCOS). It works by stimulating ovulation in women who wish to become pregnant.


💊 Prescription / Use:

  • Indications:
    • Anovulatory or oligo-ovulatory infertility
    • Polycystic Ovarian Syndrome (PCOS)
    • Unexplained infertility (off-label use)
    • Male infertility due to low sperm count (off-label)
  • Typical Dosage:
    • 50 mg once daily for 5 days, starting on day 2, 3, 4, or 5 of the menstrual cycle
    • May be increased to 100 mg daily in subsequent cycles if ovulation does not occur
    • Max 6 cycles recommended
  • Route: Oral
  • Administration: With or without food, same time each day

🔬 Nature:

  • Class: SERM (Selective Estrogen Receptor Modulator)
  • Mechanism of Action:
    • Blocks estrogen receptors in the hypothalamus
    • Causes increased secretion of FSH and LH
    • Stimulates ovarian follicular development and ovulation
  • Form: Film-coated tablet
  • Appearance: White/off-white tablet, marked “Clomiphene 50” or as per brand

🌟 Advantages:

  • Proven efficacy in ovulation induction (80% ovulate; ~40% conceive)
  • Non-invasive and cost-effective
  • Oral route—easy to administer
  • Can be used in combination with other fertility treatments (e.g., IUI)

📦 Common Packaging:

  • Blister strips of 5 tablets (1 cycle)
  • Boxes labeled with drug name, dose, manufacturing/expiry date, batch number, etc.

🧊 Storage:

  • Store at below 25°C in a dry place
  • Keep away from light, moisture, and children
  • Do not use if tablet is discolored or past expiry

⚠️ Precautions:

  • Baseline pelvic exam and hormonal assessment recommended
  • Avoid use in:
    • Pregnancy
    • Liver disease
    • Unexplained vaginal bleeding
    • Ovarian cysts not due to PCOS
  • Monitor for:
    • Ovarian hyperstimulation syndrome (OHSS)
    • Visual disturbances
    • Mood changes
    • Multiple pregnancies (twins in 5–10% of users)
  • Use cautiously in women with thyroid/adrenal dysfunction

👩‍⚕️ Patient Advice:

  • Take tablets exactly as prescribed
  • Report any vision changes, severe abdominal pain, or bloating
  • Understand the timing of ovulation for planning intercourse or IUI
  • Track menstrual cycle and any side effects
  • Inform doctor if:
    • Pregnancy occurs
    • Periods stop suddenly
  • Do not exceed more than 6 cycles without reassessment

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