🔹 Clomiphene Citrate Tablet 50 mg – As Licensed
📄 Description:
Clomiphene citrate is a selective estrogen receptor modulator (SERM) used primarily to treat female infertility due to anovulation or oligo-ovulation (especially in conditions like PCOS). It works by stimulating ovulation in women who wish to become pregnant.
💊 Prescription / Use:
- Indications:
- Anovulatory or oligo-ovulatory infertility
- Polycystic Ovarian Syndrome (PCOS)
- Unexplained infertility (off-label use)
- Male infertility due to low sperm count (off-label)
- Typical Dosage:
- 50 mg once daily for 5 days, starting on day 2, 3, 4, or 5 of the menstrual cycle
- May be increased to 100 mg daily in subsequent cycles if ovulation does not occur
- Max 6 cycles recommended
- Route: Oral
- Administration: With or without food, same time each day
🔬 Nature:
- Class: SERM (Selective Estrogen Receptor Modulator)
- Mechanism of Action:
- Blocks estrogen receptors in the hypothalamus
- Causes increased secretion of FSH and LH
- Stimulates ovarian follicular development and ovulation
- Form: Film-coated tablet
- Appearance: White/off-white tablet, marked “Clomiphene 50” or as per brand
🌟 Advantages:
- Proven efficacy in ovulation induction (80% ovulate; ~40% conceive)
- Non-invasive and cost-effective
- Oral route—easy to administer
- Can be used in combination with other fertility treatments (e.g., IUI)
📦 Common Packaging:
- Blister strips of 5 tablets (1 cycle)
- Boxes labeled with drug name, dose, manufacturing/expiry date, batch number, etc.
🧊 Storage:
- Store at below 25°C in a dry place
- Keep away from light, moisture, and children
- Do not use if tablet is discolored or past expiry
⚠️ Precautions:
- Baseline pelvic exam and hormonal assessment recommended
- Avoid use in:
- Pregnancy
- Liver disease
- Unexplained vaginal bleeding
- Ovarian cysts not due to PCOS
- Monitor for:
- Ovarian hyperstimulation syndrome (OHSS)
- Visual disturbances
- Mood changes
- Multiple pregnancies (twins in 5–10% of users)
- Use cautiously in women with thyroid/adrenal dysfunction
👩⚕️ Patient Advice:
- Take tablets exactly as prescribed
- Report any vision changes, severe abdominal pain, or bloating
- Understand the timing of ovulation for planning intercourse or IUI
- Track menstrual cycle and any side effects
- Inform doctor if:
- Pregnancy occurs
- Periods stop suddenly
- Do not exceed more than 6 cycles without reassessment