🔹 Clomiphene Citrate Tablet 100 mg – As Licensed
📄 Description:
Clomiphene citrate 100 mg is a selective estrogen receptor modulator (SERM) used to stimulate ovulation in women with infertility, especially those with anovulation or irregular ovulation, such as in Polycystic Ovary Syndrome (PCOS). The 100 mg dose is typically used if the standard 50 mg dose fails to induce ovulation.
💊 Prescription / Use:
- Indications:
- Female infertility due to anovulation/oligo-ovulation
- PCOS
- Unexplained infertility (under specialist supervision)
- Male infertility (off-label, under medical guidance)
- Dosage:
- Commonly prescribed as 100 mg once daily for 5 consecutive days
- Usually started on day 2 to day 5 of the menstrual cycle
- Should not exceed 6 ovulatory cycles in total
- Route: Oral
- Administration: Take daily at the same time; with or without food
🔬 Nature:
- Drug Class: SERM (Selective Estrogen Receptor Modulator)
- Mechanism of Action:
- Blocks estrogen receptors in the hypothalamus
- Stimulates release of FSH and LH from the pituitary
- Induces maturation and ovulation of ovarian follicles
- Form: Tablet
- Strength: 100 mg (may be one 100 mg tablet or two 50 mg tablets)
🌟 Advantages:
- Increases ovulation rates in non-responders to 50 mg
- Non-invasive oral treatment
- May be used with other fertility treatments (e.g., IUI)
- Helpful in PCOS patients with insulin resistance when combined with metformin
📦 Common Packaging:
- Supplied in blister strips or bottles of 5 or 10 tablets
- Clearly labeled with drug name, strength, batch, and expiry
🧊 Storage:
- Store at room temperature (15°C to 25°C)
- Keep in a cool, dry place, away from direct sunlight and children
- Do not use if expired or discolored
⚠️ Precautions:
- Only use under the supervision of a doctor
- Baseline pelvic exam recommended before use
- Contraindicated in:
- Pregnancy
- Liver disease
- Ovarian cysts not due to PCOS
- Unexplained uterine bleeding
- Use with caution in:
- Thyroid or adrenal dysfunction
- Endometriosis
- Elevated prolactin levels
- Risks include:
- Ovarian hyperstimulation syndrome (OHSS)
- Multiple pregnancies (especially twins)
- Visual symptoms
- Hot flashes, breast discomfort, bloating
👩⚕️ Patient Advice:
- Take the full 5-day course as prescribed
- Monitor ovulation through tests or scans
- Do not continue beyond 6 cycles without reassessment
- Report any of the following:
- Severe pelvic pain
- Visual disturbances
- Missed periods or positive pregnancy test
- Avoid alcohol and follow doctor’s fertility plan
- Keep track of menstrual cycle and intercourse timing